This project will be supervised by Dr Geoff Gobert of Queen’s University School of Biological Sciences and by Dr Sandra Telfer of the University of Aberdeen’s Institute of Biological and Environmental Sciences. The start date will be 1 October 2019.
Parasitic worm infections (helminthiases) of humans greatly impact low to medium income countries such as Thailand, by undermining health and agricultural productivity. Particularly across Southeast Asia, the expansion of urban areas and the movement of people from countries with less developed public health programs, have increased disease transmission. This project will investigate environmental influences on helminth disease transmission. Many emerging helminthiases are linked to the environment through increased contact between humans and animals, the intensification and integration of food production systems, and the expansion of migration . Therefore, effective control and treatment of many helminth diseases would benefit from better integration of clinical, veterinary and agricultural components embedded in an environmentally-driven research strategy.
Thailand is classified as an “Upper Middle Income” Country. However due the nature of helminth diseases endemic sites are significantly impacted by border countries including Cambodia, Laos and Myanmar, all of which are classified as “Least Developed” Countries. Our research team has recently established baseline human infection rates in three Thailand border regions, using highly sensitive molecular diagnostics. In the past the under-estimation of helminth infections in communities such as Thailand and our previous work in the Philippines  provides incomplete information for the development of government policy.
The proposed project will use already established human prevalence data to focus on specific locations and parasite species in endemic regions of Northern Thailand, so that environmental components of disease transmission can be identified. One class of parasites, soil transmitted helminths (STH), requires significant environmental contamination for effective disease transmission. Approximately 1.5 billion or ¼ of the world’s population are infected by STH, including the main species of Ascaris, Trichuris and hookworm. Parasite eggs found in the soil or unwashed vegetables are the primary source of infection . Similarly, food borne diseases, including the cancer-causing Opisthorchis, are contracted by consuming uncooked fish, and are linked to water sources, and the interaction between snail and fish hosts.
The student will spend considerable time in Thailand, collecting soil, vegetable and aquatic samples for diagnostics using traditional microscopy and more recently developed molecular analysis. Environmental foci of disease will be stratified using spatial modelling (GIS geographical information system) to demonstrating the importance of food and geography, in helminth disease transmission. Earth observation data will be used to build GIS layers of climatic and other relevant environmental factors, and enable intervention strategies to be assessed against likely future changes. Identification of environmental components of disease transmission will lead to predictive models for better informed government control policies.
1. Gordon CA, McManus DP, Jones MK, Gray DJ, Gobert GN: The Increase of Exotic Zoonotic Helminth Infections: The Impact of Urbanization, Climate Change and Globalization. Adv Parasitol 2016, 91:311-397.
2. Gordon CA, McManus DP, Acosta LP, Olveda RM, Williams GM, Ross AG, Gray DJ, Gobert GN: Multiplex real-time PCR monitoring of intestinal helminths in humans reveals widespread polyparasitism in Northern Samar, the Philippines. Int J Parasitol 2015, 45(7):477-483.
3. Steinbaum L, Kwong LH, Ercumen A, Negash MS, Lovely AJ, Njenga SM, Boehm AB, Pickering AJ, Nelson KL: Detecting and enumerating soil-transmitted helminth eggs in soil: New method development and results from field testing in Kenya and Bangladesh. PLoS Negl Trop Dis 2017, 11(4):e0005522.
This studentship is available to UK and other EU nationals and provides funding for tuition fees and stipend, subject to eligibility.
Candidates should have (or expect to achieve) a minimum of a 2.1 Honours degree in a relevant subject.
(1) Apply for Degree of Doctor of Philosophy in Biological Sciences;
(2) State name of the lead supervisor as the name of proposed supervisor;
(3) State QUADRAT DTP as intended source of funding;
(4) State the exact project title on the application form.
How good is research at Queen’s University Belfast in Agriculture, Veterinary and Food Science?
FTE Category A staff submitted: 33.40
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