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Identifying genomic and epigenetic factors in different subtypes of pancreatic cancer

  • Full or part time
  • Application Deadline
    Friday, November 15, 2019
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

Project Description

Despite recent advances in the treatment of pancreatic adenocarcinoma (PDAC), the median survival remains <12 months, with only 8% of patients surviving more than 5 years after diagnosis. One obstacle underlying these clinical challenges is our limited understanding of the molecular mechanisms of PDA metastasis.

Epigenetic pathway alterations are an emerging mechanism for PDA progression. Recent studies highlight a common theme of enhancer reprogramming in driving disease progression and metastasis. Further, functional and clinical outputs of this reprogramming are subtype specific and determined by deregulated master transcription factors, including a number of developmental factors that get co-opted in cancer. The Carroll laboratory has extensive experience in investigating the role of nuclear receptor transcription factors and pioneer factors in the setting of breast, prostate and more recently pancreatic cancer. The current project involves exploring the dynamic epigenetic landscape of PDAC subtypes using tools developed (qPLEX-RIME) in our laboratory. The project will explore the putative role of subtype specific pioneer factors/transcription factors in PDAC and their interplay with the dynamic stromal environment.

Preferred skills/knowledge
The student will have either a Masters research degree or an excellent undergraduate degree plus additional wet lab experience in molecular /cell biology. Previous experience with genomic technologies and pancreatic cancer biology would be an advantage but is not essential.

Please click on ’Visit Website’ for details on how to apply. You must submit an application on-line to be considered for this studentship.

Funding Notes

This project is funded by a Cancer Research UK studentship that includes full funding for University and College fees and a stipend of £19,000 per annum.

No nationality restrictions apply to Cancer Research UK funded studentships. Applications are invited from recent graduates or final year undergraduates who hold or expect to gain a first/upper second class degree (or equivalent) in a relevant subject from any recognised university worldwide.

How good is research at University of Cambridge in Clinical Medicine?

FTE Category A staff submitted: 192.05

Research output data provided by the Research Excellence Framework (REF)

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