Identifying individuals at high risk of Alzheimer’s disease


   Medical Research

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  Dr Michelle Lupton  No more applications being accepted  Competition Funded PhD Project (Students Worldwide)

About the Project

BACKGROUND

Dementia affects an estimated 353,800 Australians, with up to 80% being diagnosed with Alzheimer’s disease (AD). Despite a major research effort, an effective treatment is not available. The pathogenic process of AD begins decades prior to the clinical onset, so treatments likely need to begin early in the disease process to be of benefit.

AIM

To use known genetic and epigenetic risk factors to identify those at a high risk of developing AD, where a high proportion of individuals will be in a prodromal stage of AD.

APPROACH

To build on our current work using genetic risk prediction to identify individuals who are at high risk of AD, a subset of which will be in a prodromal disease stage. To investigate both common and rare AD genetic risk factors and test for associations with extensive phenotypic data including neuroimaging and blood-based methylation markers. Our group has access to large highly phenotyped cohorts spanning different ages and stages of dementia, including PISA (the Prospective Imaging Study of Ageing: Genes, Brain and Behaviour) based at QIMR Berghofer.

OUTCOME

The identification of individuals at high risk of Alzheimer’s disease will provide: 1) important insights into mechanisms of AD development throughout the life span; 2) the opportunity to investigate prodromal markers and allow selection of individuals for early treatment strategies.

SUITABILITY

Background in genetic epidemiology, statistics and bioinformatics. Experience in working with neuroimaging, DNA methylation or whole genome/exome sequence data is also desirable.

https://www.qimrberghofer.edu.au/our-research/mental-health-and-neuroscience/genetic-epidemiology/

Please contact the supervisors if you are interested to express your interest. Provide your CV and Academic Transcripts.

Scholarship round, your application has to be nominated by the supervisor, for QIMR Berghofer International Scholarship ends on the 30th of August:

https://www.qimrberghofer.edu.au/education/for-university-students/international-phd-scholarship/


Funding Notes

QIMR Berghofer International Scholarship ends on the 30th of August:
https://www.qimrberghofer.edu.au/education/for-university-students/international-phd-scholarship/
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