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Identifying Molecular Ageing signatures of Neural Stem Cells to uncover novel Geroneuroprotectors

Project Description

Applications Open: Friday 18th January
Application Deadline: Friday 1st March, 23:59

Supervisor Details:
Co-supervisor 1A: Dr Sandrine Thuret

Co-supervisor 1B: Dr Marc-David Ruepp
Partner Details:

Project Description:

As the ageing population increases, this project addresses a timely/important question: How to maintain cognitive health during ageing? Finding how to counteract/reverse the process driving age-related neurological decay is one of the great endeavours of the 21st Century. Ultimately, slowing-down the rate of neurobiological ageing will reduce the incidence of all age-associated neurodegenerative diseases.

The overarching goal of this project is to address this challenge by identifying (I) molecular signatures of ageing neural stem cells (NSC) and (ii) anti-neuroageing human-NSC and geroneuroprotectors.

The PhD student will be trained and exploit multi-disciplinary methodologies developed in the Thuret and Ruepp labs such as stem cell culture, inducible gene expression systems, transcriptomics analyses and connectivity mapping. For drug repositioning. The student will also be working with/at our industrial partner MSD-UK for Objective-3 with access to advanced equipment and industrial expertise. The objectives are:

• Objective-1: Uncovering molecular signatures of NSC ageing (Year 1)
• Objective-2: Identifying geroneuroprotectors (Year 1)
• Objective-3: Validating the identified geroneuroprotectors
• Ojective-4: Generating a novel accelerated model of NSC ageing + Cross-validation (Year 3 / 4)

On completion, the student will be proficient with state-of-the-art methodologies and have delivered modulators controlling NSC ageing for future interventions to maintain NSC function and sustain cognition during ageing.

How to Apply
To apply to the MRC DTP iCASE Studentships ( visit our webpages ( to submit an online application via King’s Apply ( Further information can be found on our ‘Frequently asked Questions’ pages -

Industrial Collaborative Awards in Science and Engineering (iCASE) Studentships

This PhD project is fully-funded PhD 4 year position available to start in October 2019, with the successful candidate joining the MRC Doctoral Training Partnership ( They will start immediately on their PhD project in October 2019 and will participate in all other training and cohort activities of the MRC DTP.

About Us

The objective of our Doctoral Training Partnership (DTP) ( is to select motivated and curiosity-driven students and provide them with outstanding training, tailored flexibly to their individual needs and interests. We will equip them with the intellectual and technical skills that are needed for undertaking cutting-edge biomedical research and complement this with key transferable skills (including public engagement, business development and entrepreneurship) to ensure that they emerge as well-rounded scientists, prepared for their next career stage (whether in research or outside). Our excellent clinical setting will ensure all students benefit from an understanding of the context of medical research, helping develop scientists with a strong translational ethos.


The MRC funding available supports Home/EU students within standard research council restrictions ( EU students are only eligible ( for a full studentship if they have lived, worked or studied within the UK for 3 years prior to the funding commencing. Unfortunately, we cannot accept applications from non-EU candidates.

If you have any questions, please get in touch with .

Applications Open: Friday 18th January
Application Deadline: Friday 1st March

Funding Notes

This studentship is fully funded for 4 years, including tuition fees, stipend, research consumables and conference travel:

Stipend: Students will receive a tax-free stipend for each year of study; for 2018/2019 this will be £19,277 per annum.

Bench fees: A generous allowance (£6,700) is provided for research consumables and for attending UK and international conferences. MRC DTP iCASE Students will also be eligible to apply for the Flexible Supplement Fund.

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