University of East Anglia Featured PhD Programmes
Sheffield Hallam University Featured PhD Programmes
Lancaster University Featured PhD Programmes

Identifying molecular determinants of response to oxaliplatin in metastatic bowel cancer

This project is no longer listed on and may not be available.

Click here to search for PhD studentship opportunities
  • Full or part time
    Dr S McDade
    Dr P Dunne
    Prof D Longley
  • Application Deadline
    No more applications being accepted
  • Funded PhD Project (UK Students Only)
    Funded PhD Project (UK Students Only)

Project Description

The majority of late-stage bowel cancer (BC) patients are treated with a cocktail of drugs including oxaliplatin, which is associated with significant side-effect of chronic peripheral neuropathy in approximately 50% of patients. Currently there is no effective way to identify patients who will benefit from addition of Oxaliplatin to their treatment; there is therefore an urgent unmet clinical need to limit unnecessary exposure of patients to the chronic, potentially life-altering side-effects of this agent. Dealing with the side-effects and the cost of the agent also imposes a significant financial burden on struggling healthcare systems.

Our research using cutting-edge genomic analyses at Queen’s University Belfast and as part of the S:CORT (Stratification in COloRectal cancer: from biology to Treatment prediction) consortium has begun to unravel which “sub-types” of BC benefit most from standard chemotherapy treatments. This has identified a key role for a gene called “p53” in determining response to chemotherapy.

This PhD studentship will exploit our wealth of existing patient and lab-based chemotherapy response data to identify which patients are most likely to respond to oxaliplatin-based chemotherapy and enable patients who will not benefit to avail of alternative therapies. The ultimate goals are translation of these findings into the clinic.

Funding Notes

*FUNDING CONFIRMED – Bowel and Cancer Research Grant*

Eligibility for both fees and maintenance (2020/21 TBC)

When applying, please choose 'MEDICINE' as your subject area/School.


Please visit the School of Medicine, Dentistry and Biomedical Sciences, Centre for Cancer Research and Cell Biology, website for further details about the Centre:

FindAPhD. Copyright 2005-2020
All rights reserved.