About the Project
Specific areas of research:
- cardiac metabolism
- cardiomyocyte handling of sugars (glucose, fructose)
- diastolic dysfunction
- cardiomyocyte mechanics and stiffness properties
- cardiac energetics
The successful candidate will join an active research group that utilizes state-of-the-art techniques to investigate the cellular and molecular mechanisms of heart failure. Some of these techniques include:
- isolated cardiomyocyte live cell imaging
- isolated heart perfusion
- biochemical assays
- qPCR, western blot
- cell culture of cardiomyocytes
- gene therapy in vivo
- gene manipulation in vitro (siRNA, AAV)
The successful candidate will be expected to work closely with our collaborators in Australia and within New Zealand, and present their work at national and international conferences.
Please see our lab website for more information about our research: https://www.fmhs.auckland.ac.nz/en/sms/about/our-departments/physiology/research-groups/cellular-and-molecular-cardiology.html
Fees: If you are a new international PhD student, you will pay the same annual tuition fee as New Zealand PhD students. The 2019 PhD tuition fee is NZ$7,108.80 per annum. In addition to the tuition fee, there is a Student Services Fee estimated at $847.20 for full-time study. Scholarships to cover fees and living costs are available for competitive candidates, please see the links in the funding section.
Applicants must have completed a postgraduate bachelors (honours) degree with first class or second class (division 1) honours, or a masters degree with first class or second class (division 1) honours in Biomedical Sciences, Physiology or a related subject. In addition you must have completed a significant research project, dissertation or thesis, at university level.
University of Auckland Doctoral Entry requirements:
Delbridge LM*, Mellor, KM*, Taylor DJ, Gottlieb RA (2017). Myocardial stress and autophagy: mechanisms and interventional prospects. Nature Reviews Cardiology. 14(7):412-425. *Equal 1st author. DOI: 10.1038/nrcardio.2017.35
Delbridge LM, Benson VL, Ritchie RH, Mellor KM (2016). Diabetic Cardiomyopathy: The Case for a Role of Fructose in Disease Etiology. Diabetes. 65(12):3521-3528. DOI: 10.2337/db16-0682
Delbridge LM, Bienvenu LA, Mellor KM (2016). Angiotensin-(1-9): New Promise for Post-Infarct Functional Therapy. J Am Coll Cardiol. 68(24):2667-2669. DOI: 10.1016/j.jacc.2016.10.011
Delbridge LMD, Mellor KM, Taylor DJ, & Gottlieb RA (2015). Myocardial autophagic energy stress responses—macroautophagy, mitophagy, and glycophagy. American Journal of Physiology - Heart and Circulatory Physiology, 308 (10), H1194-H1204. doi:10.1152/ajpheart.00002.2015
Mellor KM, Brimble MA, & Delbridge LM (2015). Glucose as an agent of post-translational modification in diabetes--New cardiac epigenetic insights. Life Sci, 129, 48-53. doi:10.1016/j.lfs.2014.03.020
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