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Identifying novel therapies to prevent myocardial injury in type-2-diabetes

Project Description

Type-2-diabetes (T2D) is a global epidemic associated with a major risk factor for coronary artery disease. Patients with T2D undergoing coronary artery bypass grafting (CABG) surgery have increased morbidity and mortality following cardiac surgery when compared to non-diabetic CABG patients. There are numerous risk factors that may influence myocardial injury following cardiac surgery. These include inability to precondition, increased redox oxygen species (ROS), altered glucose transport and/or metabolism. In addition, autonomic function is abnormal in T2D with additional interaction in the genesis of potentially lethal arrhythmia. As such, this may contribute to higher incidence of peri-operative myocardial infarction and arrhythmias. Thus, there is a clear need to improve myocardial protection in T2D-patients.

This project will investigate novel therapies against diabetic myocardial injury and will utilise a number of sophisticated new techniques developed by the supervisors. The successful candidate will gain a good training platform in cardiac biochemistry, pharmacology and physiology. In particular, the Langendorff model, whole heart electrophysiology, cardiac metabolomics, and redox metabolome. The candidate will be based at Professor Ng (Leicester BHF Cardiovascular Research Centre), Dr Madhani (Institute of Cardiovascular Sciences, Birmingham) and Professor Dunn (Phenome Centre Birmingham) labs. They will also link with the Midlands Cardiovascular Research Network activities.

Interviews will be held 17th May 2019

Funding details: MRC IMPACT DTP

Entry requirements

Applicants are required to hold/or expect to obtain a UK Bachelor Degree 2:1 or better in a relevant subject. The University of Leicester English language requirements apply where applicable.


UK/EU applicants only
Applicants must hold or expect to obtain UK Bachelor Degree 2:1 or better degree in Cardiovascular Sciences or Biomedical Sciences related degree. Previous experience in theoretical and practical experience in cardiovascular biology is highly desirable. Experience in biochemistry, molecular biology, data analysis and presentation skills would be an advantage.

How to apply

Please apply via:

Project / Funding Enquiries

[Professor Andre Ng, ,
Dr Melanie Madhani, ,
for informal enquiries]

Application enquiries to

Funding Notes

3.5 year MRC IMPACT DTP studentship


Ng GA, Brack KE, Patel VH, Coote JH. Autonomic modulation of electrical restitution, alternans and ventricular fibrillation initiation in the isolated heart. Cardiovasc Res 2007; 73(4):750-60.
Fitzpatrick C, Chatterjee S, Seidu S, Bodicoat DH, Ng GA, Davies MJ, Khunti K. Association of hypoglycaemia and cardiac arrhythmia risk in patients with diabetes mellitus: A systematic review and meta‐analysis. Diabetes, Obesity and Metabolism 2018; 20(9): 2169-2178.
Madhani M, Hall AR, Cuello F, Charles RL, Burgoyne JR, Fuller W, et al. Phospholemman Ser69 phosphorylation contributes to sildenafil-induced cardioprotection against reperfusion injury. Am J Physiol Heart Circ Physiol. 2010;299(3):H827-36.
Sutton TR, Minnion M, Barbarino F, Koster G, Fernandez BO, Cumpstey AF, et al. A robust and versatile mass spectrometry platform for comprehensive assessment of the thiol redox metabolome. Redox Biol. 2018;16:359-80
Dunn WB, Goodacre R, Neyses L, Mamas M. Integration of metabolomics in heart disease and diabetes research: current achievements and future outlook. Bioanalysis. 2011;3(19):2205-22.
Anderson SG, Dunn WB, Banerjee M, Brown M, Broadhurst DI, Goodacre R, et al. Evidence that multiple defects in lipid regulation occur before hyperglycemia during the prodrome of type-2 diabetes. PLoS One. 2014;9(9):e103217.

How good is research at University of Leicester in Clinical Medicine?

FTE Category A staff submitted: 72.10

Research output data provided by the Research Excellence Framework (REF)

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