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Identifying the critical downstream targets of sustained ROS production during caudal fin and heart regeneration in zebrafish


   Faculty of Biology, Medicine and Health

   Applications accepted all year round  Self-Funded PhD Students Only

About the Project

A primary goal in regenerative medicine is to identify and implement novel treatments aimed at improving our ability to regenerate injured, diseased or aged tissues and organs, including the heart. My research group has been investigating the molecular and cellular mechanisms involved in tissue formation, repair and regeneration in Xenopus and zebrafish, two vertebrate model organisms with high regenerative capacity. Recent work in my laboratory has revealed the importance of sustained reactive oxygen species (ROS) during appendage regeneration and embryonic development1-3. Furthermore our findings suggest that elevated ROS levels promote cell proliferation, growth factor signalling and metabolism; processes essential for regeneration. Although most of our work has focused on appendage regeneration, findings in zebrafish have confirmed that sustained ROS also plays an essential role during zebrafish heart regeneration4. Here we propose to extend these findings by addressing the following aim:

Identify the critical downstream targets of sustained ROS levels during caudal fin and heart regeneration in zebrafish.

Entry Requirements

Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in a related area/subject. Candidates with previous laboratory experience, particularly in cell culture and molecular biology, are particularly encouraged to apply.

How To Apply

For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (https://www.bmh.manchester.ac.uk/study/research/apply/). Informal enquiries may be made directly to the primary supervisor. On the online application form select PhD Genetics

For international students, we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences.

Equality, Diversity and Inclusion

Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. The full Equality, diversity and inclusion statement can be found on the website https://www.bmh.manchester.ac.uk/study/research/apply/equality-diversity-inclusion/”

For international students we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences. For more information please visit http://www.internationalphd.manchester.ac.uk


Funding Notes

Applications are invited from self-funded students. This project has a Band 2 fee. Details of our different fee bands can be found on our website View Website

References

1. Love, N. R. et al. Amputation-induced reactive oxygen species are required for successful Xenopus tadpole tail regeneration. Nat. Cell Biol. 15, 222–228 (2013).
2. Han, Y. et al. Ca2+-induced mitochondrial ROS regulate the early embryonic cell cycle. Cell Reports 22, 218–231 (2018).
3. Han, Y., Chen, Y., Love, N. R., Ishibashi, S. & Amaya, E. Elevated and sustained reactive oxygen species levels facilitate mesoderm formation during early Xenopus development. bioRxiv 223453 (2017). doi:10.1101/223453
4. Han, P. et al. Hydrogen peroxide primes heart regeneration with a derepression mechanism. Cell Res. 24, 1091–1107 (2014).

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