This project is part of a competition funded by the School of Medicine, Medical Sciences and Nutrition for a 4 year PhD programme. Full funding is available to UK/EU candidates only. Overseas candidates can apply for this studentship but will have to find additional funding to cover the difference between overseas and home fees (approximately £15,680 per annum).
Candidates should have (or expect to achieve) a minimum of a 2.1 Honours degree in a relevant subject. Applicants with a minimum of a 2.2 Honours degree may be considered provided they have a Merit/Commendation/Distinction at Masters level.
S. Hiraga, G.M. Alvino, F. Chang, H. Lian, A. Sridhar, T. Kubota, B.J. Brewer, M. Weinreich, M.K. Raghuraman & A.D. Donaldson (2014). Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complex. Genes & Development 28: 372
S.Hiraga, T. Ly, J. Garzon, Z. Hořejší, M. Okubo, A. Endo, C. Obuse, S.J. Boulton, A.I. Lamond and A.D. Donaldson (2017). Human RIF1 and Protein Phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation. EMBO Reports 18: 403
J. Garzón, C. Monerawela, S. Ursich, M. Lopes, S. Hiraga and A.D. Donaldson (2019). RIF1-Protein Phosphatase 1 prevents degradation and breakage of nascent DNA on replication stalling. Cell Reports, 27: 2558-2566.e4
L.P. Watts, S. Hiraga, T. Natsume, M. Kanemaki and A.D. Donaldson. The RIF1-Long splice variant promotes G1 phase nuclear bodies to protect against replication stress. Bioarchive, 859199.