About the Project
The following project will investigate the role of infiltrating immune cells within key structures at the blood-brain interface, that we hypothesise to drive neuroinflammation and concussive symptoms after head injury.
The interfaces between the periphery and the brain are now under intense scrutiny as hubs of inflammation. Two of the key blood-brain interfaces are the meninges and the choroid plexus. The meninges are a set of protective membranes that surround the brain and the choroid plexus is a structure that produces cerebrospinal fluid and is essential for a variety of brain function. Recent data has shown that the meninges and choroid plexus contain immune cells that are proposed to play important functions in the brain. Little is known of the role of these areas and their immune cells in concussion.
To address this, the project will investigate the role of innate and adaptive lymphocytes in the response to concussive injury in a clinically relevant mouse model. T cells and Innate Lymphoid Cells (ILCs) are potent regulators of the immune response, and are emerging as key players in neuroinflammation while residing in the meningeal membranes and choroid plexus. Danger signals known to activate lymphocytes, including ILCs, are also known to regulate brain function and recovery after injury, though it remains unknown how lymphocytes contribute to concussion-related symptoms.
We predict that a concussive-symptoms are driven by lymphocyte-dependent inflammation in the meninges and choroid plexus and can be targeted to improve outcome after injury.
Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in a related biological/life science, though candidates from other STEM backgrounds will be considered. Candidates with experience previous wet lab experience and especially those from underrepresented minorities are encouraged to apply.
For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (https://www.bmh.manchester.ac.uk/study/research/apply/). Informal enquiries may be made directly to the primary supervisor. On the online application form select PhD Immunology.
For international students we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences. For more information please visit http://www.internationalphd.manchester.ac.uk
As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.
Immune cell regulation of glia during CNS injury and disease.
Nature Reviews Neuroscience.
Greenhalgh AD, Healy LM, Zarruk JG, Salmon CK, Russo MV, Antel JP, McGavern DB, McColl BW, David S (2018).
Peripherally-derived macrophages modulate microglia function to reduce inflammation after CNS injury.
Sonnenberg GF, Hepworth MR (2019) Functional interactions between innate lymphoid cells and adaptive immunity.
Nature Reviews Immunology.
Melo-Gonzalez F, Kammoun H, Evren E, Papadopoulou M, Bradford B, Mabbott N, Tanes C, Fardus-Reid F, Swann JR, Bittinger K, Vallance B, Withers DR, Willinger T, Hepworth MR (2019)
Antigen presenting ILC3 regulate T cell-dependent IgA responses to colonic bacteria.
J Exp Med
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