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Immunopathogenesis of age-related macular degeneration

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  • Full or part time
    Dr M Chen
    Prof H Xu
    Dr Y Dombrowski
  • Application Deadline
    No more applications being accepted
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly in developed countries.

There are two types of advanced AMD: geography atrophy (GA) and neovascular AMD (nAMD). GA acounts for
over 80% of AMD incidence and currently there is no treatment for it. Through years of research, we now know that inflammation is an important factor that damages the macula in AMD, and properly controlled inflammation is considered as a novel approach for therapy. Inflammation is the response of the defence system of our body to take care of us and keep us in order. Inflammation is a double-edges sword: too much inflammation can cause damage to surrounding tissues and too little is ineffective in protection.

To overcome this problem, inflammation needs to be carefully controlled. In this PhD studentship, we will study how the negative regulators control the pathogenesis of dry AMD. We wish to understand why loss of negative regulators can lead to uncontrolled inflammation in AMD, and whether the development of AMD can be delayed or halted by enhancing the SIGIRR through gene therapy.

Funding Notes

FUNDING CONFIRMED – Fight for Sight

Eligible for both fees and maintenance (2020/21 TBC).

When applying, please choose 'MEDICINE' as your subject area/School.

References

Please visit the School of Medicine, Dentistry and Biomedical Sciences, Centre for Experimental Medicine, website for further details about the Centre:

http://www.qub.ac.uk/research-centres/CEM/

Related Subjects



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