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Immunoprofiling bovine responses to bacterial and viral pathogens


Project Description

‘Immunoprofiling bovine responses to bacterial and viral pathogens’ (REF no: 2017019)

4-year funded PhD
Teagasc and Trinity College Dublin

The Meade & O’Farrelly laboratories are hiring for a 4 year fully funded PhD project which aims to define the genetic, molecular and cellular variation in bovine immune responses to viral and bacterial pathogens. Using our previous studies to inform us, the overall objective is to assess the natural variation that exists in the bovine innate immune response, and how this variation correlates with disease.

Significant variation in the immune response exists between healthy individuals but without a reliable, repeatable method to measure the immune response, we cannot identify animals with sub-optimal immunity. Cattle with a poor immune response fail to thrive, do not respond well to vaccination and can act as reservoirs of disease.

This highly focused project, which has implications for our fundamental understanding of innate immunity, health and disease, is designed to provide training in cutting-edge genomics, molecular biology & immunology methods that will equip the PhD student with the skills required to be competitive in their future scientific career. You will join supportive and productive collaborative research groups studying immunological mechanisms relevant to human and animal health.

Successful applicants will have: First class honours or high 2.1 in immunology, molecular biology, genetics, or related discipline; experience in molecular biology cell culture and flow cytometry and evidence of excellent oral and written communication skills and ability to work in a team.

Studentship includes stipend, fees and costs for consumables; the project will be primarily based at the Animal Bioscience Centre, Trim, Co. Meath with some work components in the Trinity Biomedical Sciences Institute, TCD.

Applications (cover letter and CV) to:

Kieran Meade, Principal Animal Health Bioscientist, Animal & Grassland Research and Innovation Centre, Teagasc, Grange, Co. Meath. E: or

Cliona O’Farrelly, Professor of Comparative Immunology, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin. E: .
Closing date for applications: Feb 28th 2019; http://www.bovineimmunology.ie

Funding Notes

The successful applicant will be registered in the School of Biochemistry and Immunology at Trinity College Dublin but be primarily based in the new state of the art Bioscience Research Facility in Co. Meath. The Animal & Grassland Research and Innovation Centre is a major new initiative to expand Teagasc’s capacity for advanced and translational research in animal bioscience.

PhD Award is €22,000/year for 4 years. TCD postgraduate fees must be paid from this with the balance available as a stipend (~€16,000). .

References

REVIEW ARTICLE
Front. Immunol., 25 January 2019 | https://doi.org/10.3389/fimmu.2018.03072
β-Defensins: Farming the Microbiome for Homeostasis and Health

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