About the Project
This project aims to determine how PV controls elicitation of host immune responses, survival of killing by immune effectors and induction of disease symptoms. The project will involve PCR-based analysis of repetitive DNA to monitor PV; engineering of mutant strains; assaying disease phenotypes in infection models such as interaction of bacteria with immune and epithelial cells and infections in mouse models of otitis media.
Cross-institutional supervision will provide a comprehensive training opportunity across multiple institutions; bacterial genetic research undertaken with Dr. Chris Bayliss at the University of Leicester; experimental models of infection with Dr. Derek Hood at MRC Harwell; and immunological assays with Dr. Luisa Martinez-Pomares at the University of Nottingham.
For specific information on this project please contact Dr Chris Bayliss at [Email Address Removed] or by phone at 0116 2523465.
2. Moxon, Bayliss, Hood (2006) Ann Rev Genetics 40 p307-333
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