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Impact of maternal obesity on offspring adipogenesis


School of Biological Sciences

Applications accepted all year round Self-Funded PhD Students Only

About the Project

Obesity is the major health crisis of this generation. Thus, research into the mechanistic basis behind obesity is of paramount importance. In recent years it has become apparent that obesity may have its origins in prenatal and early postnatal life. For instance, maternal obesity has been shown to enhance obesity susceptibility in offspring. Very little is known about how offspring obesity susceptibility might be programmed by maternal obesity. In collaboration with Dr Felino Cagampang (University of Southampton) and Prof Roger Cox (MRC Harwell) this PhD project will aim to assess the impact of maternal obesity during pregnancy and lactation on offspring adipogenesis, the process by which new fat cells (adipocytes) are formed during development. This project will also explore potential therapeutic strategies for treating obesity by modifying adipogenesis and adipocyte metabolism. This is an exciting novel project that has enormous clinical relevance and important implications for human health.

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