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This is a 4 year BBSRC studentship under the Newcastle-Liverpool-Durham DTP. The successful applicant will receive research costs, tuition fees and stipend (£15,009 for 2019-20). The PhD will start in October 2020. Applicants should have, or be expecting to receive, a 2.1 Hons degree (or equivalent) in a relevant subject. EU candidates must have been resident in the UK for 3 years in order to receive full support. Please note, there are 2 stages to the application process.
1) Origins of lifetime health around the time of conception: causes and consequences. The Lancet 2018, 391(10132), 1842-1852.
2) Insulin and branched-chain amino acid depletion during mouse preimplantation embryo culture programmes body weight gain and raised blood pressure during early postnatal life. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2018, 1864(2), 590-600.
3) Advanced maternal age causes adverse programming of mouse blastocysts leading to altered growth and impaired cardiometabolic health in post-natal life. Human Reproduction 2016, 31(9), 1970-1980.
4) Mouse early extra-embryonic lineages activate compensatory endocytosis in response to poor maternal nutrition. Development 2014, 141(5), 1140-1150.
5) Calreticulin is required for development of the cumulus oocyte complex and female fertility. Scientific Reports 2015, 5: 14254.
6) Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male fertility. Proceedings of the National Academy of Sciences of the United States of America 2012, 109(10): 3850-3855.
7) Reductive stress selectively disrupts collagen homeostasis and modifies growth factor-independent signalling through the MAPK/Akt pathway in human dermal fibroblasts. Molecular and Cellular Proteomics 2019, 18(6): 1123-1137.
8) GnRH immunization alters the expression and distribution of protein disulfide isomerases in the epididymis. Andrology 2016, 4(5): 957-963.
9) A developmentally regulated chaperone complex for the endoplasmic reticulum of male haploid germ cells. Molecular Biology of the Cell 2007, 18(8): 2795-2804.
10) In vitro protective effects of an aqueous extract of Clitoria ternatea L. flower against hydrogen peroxide-induced cytotoxicity and UV-induced mtDNA damage in human keratinocytes. Phytotherapy Research 2018, 32(6), 955-1144.