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Impact of transposable elements in parasite genomes


Department of Pathology

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Dr A Protasio No more applications being accepted Competition Funded PhD Project (UK Students Only)

About the Project

Transposable elements are mobile genetic entities that can jump from place-to-place within the genome. They are present in almost all the genomes studied so far, from bacteria to humans, occupying varying proportions of the genome space. They occupy a significant proportion of the genomes of parasitic helminths, a group of clinical and veterinary pathogens responsible for millions of deaths and great economic losses in communities around the world. Using computational biology and genome analysis tools, you will unravel the diversity of transposable elements in parasitic helminths, their role in speciation, adaptation and potential role in the emergence of drug resistance.

Funding Notes

Funding* will cover the student’s stipend at the current Research Council rate and University Fees. The studentship will be funded for three years in the first instance subject to eligibility, with the possibility of additional funding in the fourth year depending on circumstances.

*The studentships are available to students who qualify for Home fees

Applications from ineligible candidates will not be considered.

(http://www.graduate.study.cam.ac.uk/courses/directory/blpapdpth/requirements)

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

References

Wangwiwatsin A, Protasio AV, Wilson S, Owusu C, Holroyd NE, Sanders MJ, et al. Transcriptome of the parasitic flatworm Schistosoma mansoni during intra-mammalian development. PLoS Negl Trop Dis. 2020 May 6;14(5):e0007743.
Protasio AV, van Dongen S, Collins J, Quintais L, Ribeiro DM, Sessler F, et al. MiR-277/4989 regulate transcriptional landscape during juvenile to adult transition in the parasitic helminth Schistosoma mansoni. PLoS Negl Trop Dis. 2017 May;11(5):e0005559.
Protasio AV, Tsai IJ, Babbage A, Nichol S, Hunt M, Aslett MA, et al. A systematically improved high quality genome and transcriptome of the human blood fluke Schistosoma mansoni. PLoS Negl Trop Dis. 2012 Jan;6(1):e1455.
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