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Improved biomanufacturing and downstream processing of vaccines and biopharmaceuticals Update by Supervisor

Project Description

We invite applications for a four-year EPSRC-funded iCASE PhD studentship to work under the supervision of Prof Mark Dickman and Dr Jagroop Pandhal at the University of Sheffield in collaboration with Dr Dave Gervais and Dr Tapasvi Modi at Porton Biopharma Ltd.
The global market for biopharmaceuticals and vaccines in 2019 is expected to reach US$269.3 billion. This multidisciplinary project addresses an important Industrial challenge associated with the manufacturing and downstream processing of vaccines and biopharmaceuticals. This project is in collaboration with the industrial partner Porton Biopharma LTD which are currently the manufacturer of Erwinase and Anthrax vaccine.
In order to meet the growing demand of these products worldwide, significant improvements in the manufacturing processes are needed. Current manufacturing processes are lengthy and involve many different steps. This projects aims to develop novel methods to improve current biomanufacturing and downstream processing of these important products, including the generation of novel high affinity nucleic acid ligands (aptamers) to Erwinase and Anthrax vaccine. In addition, this project aims to develop novel bioanalytical methods for the detection, purification, identification and quantification of important biopharmaceuticals and vaccines including Erwinase and Anthrax vaccine.

Funding Notes

This is a prestigious EPSRC iCASE PhD studentship which is supported by Porton Biopharma who will enhance its tax-free stipend to £16,700 p.a (subject to annual increase) and will provide periods of placement within the company's research laboratories in Porton Down, Salisbury UK.


Applicants should have a strong background in bioscience, biological engineering or chemistry with an interest in analytical science, be a good communicator and be highly motivated. The ideal applicant should have an interest in working as part of an interdisciplinary team. The studentship is open to UK students and also to EU students who fulfil the eligibility criteria set by EPSRC:

For more information contact:
[email protected]

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