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Improving erythroid culture and reticulocyte maturation efficiency

  • Full or part time
  • Application Deadline
    Tuesday, December 31, 2019
  • Awaiting Funding Decision/Possible External Funding
    Awaiting Funding Decision/Possible External Funding

Project Description

An EU funded Horizon 2020 Marie Sklodowska-Curie Innovative Training Network (MSC ITN) PhD position is available in the laboratory of Dr Ashley Toye at the University of Bristol for 3 years. The Toye laboratory is interested in the study of the process of erythropoiesis in health and disease and also in the manufacture of red blood cells for therapeutic use. The University of Bristol’s specific contribution to the EU funded EVIDENCE (Erythrocytes properties and viability in dependence of flow and extra-cellular environment) consortium, is to research the process of reticulocyte maturation further and help develop more efficient erythroid culture methodology. An improved understanding of these processes may lead to more cost-effective erythroid culture processes and new ways to manipulate cultured reticulocytes to mature which will extend storage.

Funding
EVIDENCE ITN is an EU funded international consortium of academic research centres, diagnostic labs, blood supply centres, and small companies that combines basic and translational research to improve diagnostic and therapeutic approaches on erythrocytes and during erythropoiesis. More details about the consortium can be found at the EVIDENCE website https://evidence.eurice.eu/. The overall objective of EVIDENCE research program is the exploration of the properties and behaviour of RBCs under flow conditions and in vivo to understand pathophysiology and to design novel diagnostic devices. Furthermore, EVIDENCE will explore the effect of shear stress in bioreactors, allowing the efficient production of RBCs in vitro with the goal to produce RBC for transfusion.

The MSC ITN programme offers highly competitive and attractive salary. The successful candidate will receive a salary in accordance with the regulations for MSC Fellows/early stage researchers (ESRs). Exact salary will be confirmed upon appointment but will involve a generous Living Allowance and monthly mobility allowance depending on the successful candidate’s personal family situation. This PhD position will likely provide experience of erythroid culture, cell biology, imaging, flow cytometry, microfluidics and proteomics. In addition to their individual scientific projects, all fellows benefit from further continuing education, which includes internships and secondments, a variety of training modules as well as transferable skills courses and active participation in workshops and conferences https://evidence.eurice.eu/.

Selection criteria
As this is an ITN program the University of Bristol can only consider candidates from within the EU. Candidates residing in the United Kingdom or EU candidates who have resided in the UK for longer than 12 months during the past 3 years are excluded from applying for this specific position but are strongly encouraged to apply for the other 14 ESR positions available with partners of the consortium outside UK. All competitive candidate details may be shared specifically and only for consideration by other partners within the EVIDENCE consortium. This increases your chance of obtaining a studentship but if you do not want your details to be shared across the consortium please specifically state this in you cover letter. More details of the other available RELEVANCE projects are found on the consortium website https://evidence.eurice.eu/.

Applicants should send their complete applications in one single PDF by email to Dr Ashley Toye () or alternatively if you would like to apply for more than one ESR email your applications to: and also copy in Dr Toye.
Each application should clearly state the preference for ESR5 and/or other positions, provide a cover letter, a CV detailing scientific experience and copy of qualification certificates and provide a contact information of appropriate 2 references.
For further details of ESR5 or other projects, please refer to the website: https://evidence.eurice.eu/ or contact Dr Ashley Toye by email with EVIDENCE ESR5 as the subject reference.

The application closing date is 31st December 2019.
Preselection will be conducted by Skype in early January. Final selection will be held 24-26 January in Amsterdam at an EVIDENCE kick-off meeting.

Erythrocytes properties and viability in dependence of flow and extra-cellular environment (Acronym: EVIDENCE) is a EU funded international consortium is a EU funded international consortium of academic research centres, diagnostic labs, blood supply centres, and small companies that combines basic and translational research to improve diagnostic and therapeutic approaches on erythrocytes and during erythropoiesis. More details about the consortium can be found at the RELEVANCE website. http:// https://evidence.eurice.eu/

Funding Notes

See above

Related Subjects

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