The vision of the ACRC is to play a vital role in addressing the Grand Challenge of ageing by transformational research that will support the functional ability of people in later life so they can contribute to their own welfare for longer. With fresh and diverse thinking across interdisciplinary perspectives our academy students will work to creatively embed deep understanding, data science, artificial intelligence, assistive technologies and robotics into systems of health and social care supporting the independence, dignity and quality-of-life of people living in their own homes and in supported care environments.
The ACRC Academy will equip future leaders to drive society’s response to the challenges of later life care provision; a problem which is growing in scale, complexity and urgency. Our alumni will become leaders in across a diverse range of pioneering and influential roles in the public, private and third sectors.
Genome-wide association studies can reliably identify genetic variants associated with traits/disease; these can be combined into a single polygenic score and used for prediction. This project integrates polygenic scores for ageing-related diseases (e.g., frailty, stroke, dementia) with environmental predictors (e.g., SES, social support, exercise) to test whether positive aspects of the environment can lower a person’s genetic risk of adverse ageing. By considering genes and environment, we can refine prediction of ageing outcomes and estimate environmental effects free from genetic bias, thus identifying optimal intervention targets. The project’s findings will inform a Citizens’ Jury on the topic of personalised genomics.
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