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Improving purity of crystalline pharmaceutical products using advanced nano-tomography techniques

Project Description

Filtration is classically used to separate product crystals from the impure mother liquor from which they were crystallized. For this to be completely effective the residual mother liquor must be removed by washing with a suitable solvent. This is an essential step in pharmaceutical manufacturing however it has not been subject to intense scrutiny and most processes are developed empirically. This PhD project sets out to use nano-computed tomography (nano-CT) to obtain high-resolution cross-sectional images using a beam of X-rays with a focal spot of ca 400nm. The project will also examine other tomography techniques, potentially including the I13 beam line at the DIAMOND, the UK synchrotron which would allow the collection of real time data resolutions as small as 50nm. These innovative techniques will yield unprecedented information on the washing step, leading to optimisation of the drug manufacture process.

In addition to undertaking cutting edge research, students are also registered for the Postgraduate Certificate in Researcher Development (PGCert), which is a supplementary qualification that develops a student’s skills, networks and career prospects.

Information about the host department can be found by visiting:

Funding Notes

This PhD project is awaiting funding outcome.

Students applying should have (or expect to achieve) a minimum 2.1 undergraduate degree in a relevant engineering/science discipline, and be highly motivated to undertake multidisciplinary research.

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