You will use an extensive toolbox of genetic and imaging techniques to exploit the benefits of transparent zebrafish to understand the dynamics of neutrophilic inflammation in vivo. You will study neutrophil behaviours during inflammation and infections, focusing on a specialised and highly dynamic behaviour of neutrophils called “swarming” - similar to behaviours observed in insect/bird movements. After tissue injury or infection, neutrophils responding to inflammatory signals release amplification signals that attract other neutrophils into swarms. The initiating events are poorly characterised and the mechanisms determining neutrophil retention in swarms and how these ultimately lead to dissolution are unknown.
You will be trained to use cutting-edge intravital microscopy (lightsheet and spinning disk) alongside genetic manipulation (CRISPR-Cas9 and transgenics) to elucidate the molecular events initiating neutrophil swarms. You will also determine the molecular signals retaining neutrophils within swarms and how these control swarm resolution. A screen for new small molecule accelerators of swarm resolution will be performed that may have important implications for diseases that involve chronic neutrophilic inflammation (eg COPD).
You will be well trained in molecular biology, zebrafish and microscopy techniques, as well as learning how to write and present your science.
You will be part of a dynamic and friendly group at the University of Sheffield, UK, working in the laboratories of Professor Stephen Renshaw and Dr Philip Elks.
For more information please contact Prof Stephen Renshaw ([Email Address Removed], http://renshaw.group.shef.ac.uk/) or Dr Philip Elks ([Email Address Removed], https://elkslab.weebly.com/).
Trans-national mobility (i.e. move from one country to another): This an essential requirement of this Marie Skłodowska-Curie Innovative Training Network studentship. Researchers can be of any nationality. At the time of recruitment by the host organisation, researchers must not have resided or carried out their main activity (work, studies, etc) in the country of their host organisation for more than 12 months in the 3 years immediately before the reference date. Compulsory national service and/or short stays such as holidays are not taken into account. Applicants must also be prepared to be seconded for short periods (from several weeks up to maximally 30% of the recruitment period) to other network partners to carry out part of their research work
The Euraxess page for more details is: http://www.inflanet.eu/
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