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Individual and combined effects of genomic variation and environment on lung function and COPD in African populations (T2/5)

  • Full or part time
  • Application Deadline
    Thursday, December 05, 2019
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

Chronic obstructive pulmonary disease (COPD), characterised by reduced lung function, affects 65 million people globally, reduces quality of life, and will become the third-leading cause of death. The supervisory team has discovered genomic variants associated with lung function and COPD in European-ancestry populations, but the genetic and environmental determinants of disease remain understudied in African populations. In the AWI-Gen study, including ~12,500 participants from communities in South Africa, Kenya, Ghana and Burkina Faso, you will study the influence of smoking and indoor air quality on lung function.

Through genome-wide association studies in the AWI-Gen population, you will study the relationship between millions of genomic variants and lung function. Follow-up work will include replication of signals, bioinformatic analyses to understand function and the study of gene-environment interactions. You will have an opportunity to develop skills in epidemiology and statistical genetics, including inference from epidemiology studies, analysis of genome-wide association studies (in particular, in diverse African populations), bioinformatics and an understanding of the design, conduct and utility of cohort studies to advance health.

You will be based at the University of Leicester, UK, with an opportunity for funded placement in South Africa, Ghana, Kenya or Burkina Faso during and after the PhD.

Entry Requirements

UK Bachelor Degree with at least 2:1 in a relevant subject or overseas equivalent.

University of Leicester English language requirements apply.

This project is available for UK/EU/International students.

How to Apply

Application advice and application link:

Funding Notes

This project is funded by the Wellcome Trust Doctoral Training Programme.

Stipend for the PhD: Year 1 £19,919; Year 2 £21,542; Year 3 £23,298; Year 4 £23,997 (rates as of September 2019).

4 year PhD fee waiver at UK/EU rates.

International applicants need to ensure they can fund the difference between UK/EU and international fees for the duration of their studies.

We also will offer 2 fully funded places to international applicants from Lower-middle income countries per year. These will provide a full overseas fee waiver and stipend for 4 years.

Related Subjects

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