Our basic research aims to understand fundamental mechanisms of inflammation, such as the activation of the NLRP3 inflammasome. The NLRP3 inflammasome is a large multi-molecular protein complex that forms in cells of the innate immune system and its activation drives the release of proinflammatory cytokines of the interleukin-1 family, and a type of cell death called pyroptosis. Through understanding the regulation of NLRP3 we can target it in disease. An area of major unmet clinical need is in the management of brain tumours. Within the GJBRC our primary focus is on glioblastoma and vestibular schwannoma (VS). In VS the tumours go from a static to a growth phase that is dependent on an inflammatory response and in GBM an inflammatory response may drive treatment resistance. There is some evidence to suggest that NLRP3 could be involved in tumorigenesis. With access to brain tumour tissue we will be able to interrogate the inflammatory responses present and establish new ways of targeting or managing inflammation in brain tumours.
Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in a related area/subject. Candidates with previous laboratory experience are particularly encouraged to apply.
How To Apply
For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (https://www.bmh.manchester.ac.uk/study/research/apply/). Informal enquiries may be made directly to the primary supervisor. On the online application form select the appropriate subject title.
For international students, we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences.
Equality, Diversity and Inclusion
Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. The full Equality, diversity and inclusion statement can be found on the website https://www.bmh.manchester.ac.uk/study/research/apply/equality-diversity-inclusion/”