Technical University Dresden Featured PhD Programmes
University of Leeds Featured PhD Programmes
University of Reading Featured PhD Programmes

Inflammation, the immune system and neurological disease


Faculty of Biology, Medicine and Health

About the Project

Inflammation is now recognised as a key contributor to neuronal injury in both acute and chronic neurodegenerative disease. Many studies in this area have focussed on the post-injury inflammatory response and in particular on the role of specific cytokines in the central nervous system. A key mediator, identified from both experimental and clinical studies, is interleukin-1 and this has been the focus of much of our research for the last few years. Increasing interest has now also been focussed on the peripheral response to injury and that the inflammatory status of an individual represents a key risk factor. This is particularly true for acute conditions, such as stroke, where preceding infection is a major risk factor, but this may also be true for chronic conditions, such as epilepsy and Alzheimer’s disease.

This project will assess the contribution of inflammation, peripheral and central, before and after injury, using appropriate experimental paradigms.

Funding Notes

This project has a Band 3 fee. Details of our different fee bands can be found on our website. For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website. Informal enquiries may be made directly to the primary supervisor.

References

• Denes A, Pinteaux E, Rothwell NJ & Allan SM (2011) Interleukin-1 and stroke: biomarker, harbinger of damage, and therapeutic target. Cerebrovasc Dis. 32:517-27.

• Brough D, Tyrrell PJ & Allan SM (2011) Regulation of interleukin-1 in acute brain injury. Trends Pharmacol. Sci. 32:617-22.

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here

The information you submit to The University of Manchester will only be used by them or their data partners to deal with your enquiry, according to their privacy notice. For more information on how we use and store your data, please read our privacy statement.

* required field

Your enquiry has been emailed successfully



Search Suggestions

Search Suggestions

Based on your current searches we recommend the following search filters.



FindAPhD. Copyright 2005-2020
All rights reserved.