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Information and function in synthetic genetic polymers

  • Full or part time
    Dr P Holliger
  • Application Deadline
    Tuesday, December 03, 2019
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description


Life is based on the capacity of the nucleic acids DNA and RNA to encode, store and propagate genetic information. However, whether their unique role in biology reflects evolutionary history or fundamental functional constraints, whether nature’s “choice” was shaped by chance or necessity, is currently unknown.

The Holliger lab uses synthetic biology approaches to explore these fundamental questions of biological form and function towards a better understanding of the chemical etiology of the genetic apparatus shared by all life on earth.

Previously we have shown that diverse synthetic genetic polymers (called XNAs), based on nucleic acid architectures not found in nature, can mediate both heredity and evolution, two hallmarks of life ([1] Science, 336: 341) as well as catalysis ([2] Nature, 518: 427), another fundamental property of biopolymers.

Progress in this area has fundamental implications for the understanding of abiogenesis and the chemical constraints for the emergence of life, another active interest of the lab ([3] Nature Chem. 7: 502; [4] Science. 332: 209; [5] eLife. 7: e35255).

Potential projects would be focused on these two general areas including 1) exploring the informational, structural and catalytic potential of novel genetic polymers with a view to advance our understanding of the parameters required for the molecular encoding of information and 2) advancing RNA-catalyzed RNA synthesis towards a system capable of self-replication and evolution.


Funding Notes

Please see the LMB PhD website for further details: View Website

References


[1] Pinheiro VB et al (2012) Synthetic genetic polymers capable of heredity and evolution. Science, 336 : 341-44

[2] Taylor AI, Pinheiro VB, Smola MJ, Morgunov AS, Peak-Chew SY, Cozens C, Weeks KM, Herdewijn P & Holliger P. (2015) Catalysts from synthetic genetic polymers. Nature, 518 : 427-30

[3] Mutschler H, Wochner A & Holliger P. (2015) Freeze-thaw cycles as drivers of complex ribozyme assembly. Nature Chemistry 7 : 502-8

[4] Wochner A, Attwater J, Coulson A & Holliger P (2011) 
Ribozyme-catalyzed transcription of an active ribozyme.
 Science. 332 : 209-211

[5] Attwater J, Raguram A, Morgunov AS, Gianni E & Holliger P (2018) Ribozyme-catalysed RNA synthesis using triplet building blocks. eLife. 7: e35255. doi: 10.7554 / eLife.35255

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