Inhalers are widely used to treat chronic respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD). Several 100 millions of patients worldwide rely on pressurised metered dose inhalers (pMDIs) or dry-powder inhalers (DPIs) to manage their condition and ensure a good quality of life.
Thermofluids and Healthcare Engineering research groups have opportunities to contribute to research, development and commercialisation of pharmaceutical inhaler products and improve the quality of life of patients. This project will investigate:
• Fundamentals of aerosol production processes in pressurised metered dose inhalers - development of next-generation inhaler devices based on green (HFO) propellants: multiphase flow, atomisation & sprays, phenomenological modelling, CFD modelling, device development, next-generation propellants
• Fundamentals of fluidisation processes in dry-powder inhalers: multiphase flow, fluidisation, phenomenological modelling, CFD modelling, device development
• Drug deposition and transport processes governing delivery and uptake of inhaled therapeutic agents: drug-device interactions, drug deposition in airways, filtration processes, muco-ciliary clearance, diffusion, trans-membrane transport
• Patient-inhaler interactions - understanding and controlling patient-specific factors and human factors in inhaler use: multiphase flow, CFD modelling, drug deposition processes, flow-tissue interaction (FSI), human factors
• Patient-centered inhaler devices - multi-disciplinary research to apply advances in sensor array technology and embedded intelligence: inhaler design, smart inhalers, sensor technology, health condition monitoring, digital integration, human factors
• Nasal drug delivery: fundamentals of drug delivery to brain via the nasal cavity
Applicants should have, or expect to achieve, at least a 2:1 Honours degree (or equivalent) in a relevant engineering or science discipline.
A relevant Master’s degree and/or experience in one or more of the following will be an advantage: computational fluid dynamics, flow modelling, chemical engineering, multiphase flow, atomisation & sprays, fluidisation
How to apply
All applications should be made online. Under programme name select Mechanical and Manufacturing Engineering. Please quote reference number: HVUF2018