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Inhalers and inhaler technology: contributing to research of pharmaceutical inhaler products and improving the quality of life of patients - Ref: HVUF2018

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

About This PhD Project

Project Description

Inhalers are widely used to treat chronic respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD). Several 100 millions of patients worldwide rely on pressurised metered dose inhalers (pMDIs) or dry-powder inhalers (DPIs) to manage their condition and ensure a good quality of life.

Thermofluids and Healthcare Engineering research groups have opportunities to contribute to research, development and commercialisation of pharmaceutical inhaler products and improve the quality of life of patients. This project will investigate:

• Fundamentals of aerosol production processes in pressurised metered dose inhalers - development of next-generation inhaler devices based on green (HFO) propellants: multiphase flow, atomisation & sprays, phenomenological modelling, CFD modelling, device development, next-generation propellants

• Fundamentals of fluidisation processes in dry-powder inhalers: multiphase flow, fluidisation, phenomenological modelling, CFD modelling, device development

• Drug deposition and transport processes governing delivery and uptake of inhaled therapeutic agents: drug-device interactions, drug deposition in airways, filtration processes, muco-ciliary clearance, diffusion, trans-membrane transport

• Patient-inhaler interactions - understanding and controlling patient-specific factors and human factors in inhaler use: multiphase flow, CFD modelling, drug deposition processes, flow-tissue interaction (FSI), human factors

• Patient-centered inhaler devices - multi-disciplinary research to apply advances in sensor array technology and embedded intelligence: inhaler design, smart inhalers, sensor technology, health condition monitoring, digital integration, human factors

• Nasal drug delivery: fundamentals of drug delivery to brain via the nasal cavity

Entry requirements

Applicants should have, or expect to achieve, at least a 2:1 Honours degree (or equivalent) in a relevant engineering or science discipline.

A relevant Master’s degree and/or experience in one or more of the following will be an advantage: computational fluid dynamics, flow modelling, chemical engineering, multiphase flow, atomisation & sprays, fluidisation

How to apply

All applications should be made online. Under programme name select Mechanical and Manufacturing Engineering. Please quote reference number: HVUF2018

Preferred start date: 1st April 2019

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