The major goal of the project is a rational design of novel binders, which are able to effectively disrupt protein-protein interactions (PPIs) involved in numerous pathological processes. The work will focus on structurally characterized PPIs implicated in cancer development and viral replication. The design of new ligands will be based on high-throughput screening. Subsequent optimization of acquired hits will be performed by means of medicinal chemistry strategies combined with extensive structural studies and molecular docking.
How to apply
To apply for a PhD study at IOCB Prague, you must hold a Master’s degree (MSc) or the equivalent of the MSc in similar field (four or five year undergraduate degree). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five months after the application deadline.