Viral methyltransferses (MTases) play an essential role in the capping of the newly synthesized viral RNA during the replication process. In flaviviruses, the cap usually consists of 7-N-methylated guanosine 5’- triphosphate and 2’-O-methyladenosine and the MTases are responsible for methylation of both guanosine nucleobase and adenosine sugar moiety. The project will be focused on the synthesis of novel inhibitors targeting these enzymes, which are highly conserved among numerous flaviviruses that are responsible for important human diseases such as tick-borne encephalitis, Dengue, West Nile and Yellow fevers.
How to apply
To apply for a PhD study at IOCB Prague, you must hold a Master’s degree (MSc) or the equivalent of the MSc in similar field (four or five year undergraduate degree). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five months after the application deadline.
For more information visit our website “Call for PhD applications 2020”: https://www.uochb.cz/en/phd-program
If you decided to apply, please do so online via our application form: https://www.uochb.cz/en/call-for-phd-applications