About the Project
This project will form part of an on-going programme of work in Professor Day’s lab (in collaboration with Professor Paul Bishop, University of Manchester) aimed at understanding the molecular basis of AMD. This research project may include fluorescent microscopy, cell biology, molecular biology and protein biochemistry.
Informal enquiries may be made directly to the primary supervisor.
Clark, S.J., Perveen, R., Hakobyan, S., Morgan, B.P., Sim, R.B., Bishop, P.N. & Day A.J. Impaired binding of age-related macular degeneration-associated complement factor H 402H allotype to Bruch’s membrane in human retina. (2010) J. Biol. Chem. 285, 30192-30202.
Clark, S.J., Ridge, L.A., Herbert, A.P., Hakobyan, S., Mulloy, B., Lennon, R., Wurzner, R., Morgan, B.P., Urhin, D., Bishop, P.N. & Day, A.J. Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regions. (2013) J. Immunol. 190, 2049-2057.
Langford-Smith, A., Keenan, T.D.L., Clark, S.J., Bishop, P.N. & Day, A.J. The role of complement in Age-related Macular Degeneration: heparan sulphate, a ZIP code for complement factor H? (2014) J. Innate Immunity 6, 407-416.
Keenan, T.D.L., Pickford, C.E., Holley, R.J., Clark, S.J., Lin, W., Dowsey, A.W., Merry, C.L., Day, A.J. & Bishop, P.N.* Age-dependent changes in heparan sulfate in human Bruch’s membrane: implications for age-related macular degeneration. (2014) Invest. Ophthalmol. Vis. Sci. 55, 5370-5379.
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