This project has a Band 2 fee. Details of our different fee bands can be found on our website (View Website). For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (View Website).
Informal enquiries may be made directly to the primary supervisor.
Prosser, B.E., Johnson, S., Roversi, P., Herbert, A.P., Blaum, B.S., Tyrrell, J., Jowitt, T.A., Clark, S.J., Tarelli, E., Uhrin, D., Barlow, P.N., Sim, R.B., Day, A.J. & Lea, S.M. Structural basis for complement factor H linked age-related macular degeneration. (2007) J. Exp. Med. 204, 2277-2283.
Clark, S.J., Perveen, R., Hakobyan, S., Morgan, B.P., Sim, R.B., Bishop, P.N. & Day A.J. Impaired binding of age-related macular degeneration-associated complement factor H 402H allotype to Bruch’s membrane in human retina. (2010) J. Biol. Chem. 285, 30192-30202.
Clark, S.J., Ridge, L.A., Herbert, A.P., Hakobyan, S., Mulloy, B., Lennon, R., Wurzner, R., Morgan, B.P., Urhin, D., Bishop, P.N. & Day, A.J. Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regions. (2013) J. Immunol. 190, 2049-2057.
Langford-Smith, A., Keenan, T.D.L., Clark, S.J., Bishop, P.N. & Day, A.J. The role of complement in Age-related Macular Degeneration: heparan sulphate, a ZIP code for complement factor H? (2014) J. Innate Immunity 6, 407-416.
Keenan, T.D.L., Pickford, C.E., Holley, R.J., Clark, S.J., Lin, W., Dowsey, A.W., Merry, C.L., Day, A.J. & Bishop, P.N.* Age-dependent changes in heparan sulfate in human Bruch’s membrane: implications for age-related macular degeneration. (2014) Invest. Ophthalmol. Vis. Sci. 55, 5370-5379.