PROJECT
Brain tumours are the leading cause of cancer-related death in children. Medulloblastoma is the most common malignant paediatric brain tumour with a third of all patients metastatic at diagnosis. Group3 subtype (G3) predominates in infants and young children and has the lowest survival rate. Current standard-of-care treatment is multi-modal and highly aggressive, leaving young survivors with severe long-term cognitive dysfunction, growth impairments, and secondary malignancies. The advancement of G3 therapies for improved treatment solutions has been restricted by the paucity of appropriate cell models that recapitulate G3 microenvironment and the ability to understand the molecular composition defining G3 cellular architecture that result in varied treatment efficiency. Therefore, the aims of this project are to:
1. To apply cutting-edge single-cell technology to characterise the clonal landscape and regulatory networks that drive G3 metastasis, chemosensitivity and relapse in next-generation 3D preclinical tumour models.
2. Identify predictive biomarkers and gene targets for improved G3 clinical treatment.
This an exciting opportunity to engage in a high-impact research project that aims to connect advanced bioinformatics with clinical medicine. The student will develop technical skills through first-class training within a cross-disciplinary supervisory team and will play a key role in advancing novel therapeutic approaches.
Eligibility
The MRC AIM studentships are available to UK and international* applicants who meet the academic criteria.
Full details on eligibility, including residence requirements can be found on the Full Eligibility Criteria or on the UKRI website
*funding restrictions apply to international applicants
Academic requirements
Minimum qualifications and experience to undertake a research degree are detailed in the QAA UK Quality for Higher Education. For some subject areas, there is also an expectation that an individual will have undertaken a Masters qualification before beginning a doctoral programme.
Candidates should possess the relevant qualifications and/or experience to demonstrate a capability to undertake a doctorate, which will be assessed during the recruitment process. More details can be found on the MRC website
TO APPLY please refer to the MRC AIM website https://more.bham.ac.uk/mrc-aim/phd-opportunities/
Completed applications and references to be submitted to [Email Address Removed] before the deadline of 09:00 (GMT) Monday 16 January 2023.
All applicants will be contacted by week commencing 13 February 2023 with notification of the outcome of their application.
Shortlisted and reserve candidates will be invited to a Zoom pre-interview briefing and question and answer session on Thursday 16 February
2023 09:00 – 10:30 GMT and will be invited for interview on either Monday 27 February, Tuesday 28 February or Wednesday 1 March 2023
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