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Interactions of small molecules and salts with biomembranes


School of Science

, Assoc Prof Tam Greaves Applications accepted all year round Funded PhD Project (Students Worldwide)

About the Project

This is an opportunity to join a supportive research group in the School of Science at RMIT University, Melbourne. This physical chemistry-based project aims to study the influence of chemical structure, charge, and physical properties of novel salts and small molecules on lipid biomembranes. Biomembranes are complicated self-assembled structures which control which species can cross into the cell’s interior. For applications such as cryopreservation, it is essential to be able to control this cell permeation, and to understand any other changes that are being made to the cell membrane. The project will initially involve using model membranes, and later cells. Extensive characterisation will be performed, including using small angle X-ray scattering (SAXS), atomic force microscopy (AFM), and physicochemical characterisation methods. It will suit candidates with an interest in interdisciplinary research combining physics, chemistry, biology, and materials science. 

This is an exciting project, where the fundamental knowledge obtained will contribute to ongoing research in nanomedicine and improving health outcomes. The suitable candidate will gain expertise with a broad range of synthesis and characterisation techniques, and will have the opportunity to use large facilities, such as the Australian Synchrotron.


Funding Notes

This project is associated with a fully funded PhD stipend for 3 years, with the possibility to extend for an additional 6 months.

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