Cancer arises in part from intrinsic molecular and cellular alterations. For instance, loss of major DNA damage response genes such as BRCA1/2 has long been known to predispose individuals to multiple cancer types. Equally, ubiquitous environmental toxins such as alcohol and plastic have emerged as potential promoters of cancer initiation. This PhD project will study the interplay between intrinsic and extrinsic factors in carcinogenesis.
Our prior work have established the role of deregulated DNA damage response pathway in instigating the hallmarks of cancer. In this project, we will focus on how this deregulation (as driven intrinsically by faulty genes) cooperates with environmental toxins to enhance genetic instability, ultimately leading to malignancy. Using a host of preclinical models and clinical specimens, the selected student will investigate features that characterise early events of carcinogenesis. Key laboratory techniques for the project include molecular and cellular profiling, multi-omics analyses and advanced live imaging. By integrating data from in-silico, in-vitro, in-vivo/ex-vivo experimental models, our goal is to discover and develop clinically actionable biomarkers implicated in cancer development. There are also ample opportunities to collaborate with other expert biomedical scientists, genetic epidemiologists and clinicians in the field.
Our laboratory is a dynamic, hard-working and international research group situated in the School of Cellular & Molecular Medicine at the University of Bristol. We have direct access to nationally leading facilities such as the Bristol Proteomics Facility and the Wolfson Bioimaging Facility. This exciting position will be well-suited for a highly industrious and motivated individual who is keen to work on fundamental research to address clinically pressing questions. A first or upper second-class honours degree (or international equivalent) in related disciplines is expected for entry to the PhD programme. Those who have secured funding or who intend to apply for funding are encouraged to contact us.
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