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Interrogating the role of KDM5 in inflammation


School of Natural and Environmental Sciences

Dr Katrina Madden , Prof Akane Kawamura , Prof S Rocha Friday, January 22, 2021 Competition Funded PhD Project (Students Worldwide)
Newcastle United Kingdom Cell Biology Developmental Biology Genetics Immunology Molecular Biology Organic Chemistry Pharmacology

About the Project

The Jumonji C histone demethylases (JmjC KDMs) are heavily involved in the regulation of cell function, through controlling gene expression and modifying proteins. They represent a key target for a range of diseases due to their implication in diseases such as cancer, immune disorders and neurodegenerative disease. Recent work has generated a considerable amount of detail about how these enzymes work, but we need better chemical tools in order to fully interrogate the role of each member of the JmjC KDM family in ordinary cell signalling and behaviour. This project aims to generate new, selective chemical tools for KDM5 and elucidate more about its role in oxygen sensing and inflammation.

This project will be primarily based in the lab of Dr Kate Madden (Newcastle University), with the student co-supervised by Professor Akane Kawamura (Newcastle University) and Professor Sonia Rocha (University of Liverpool). The project will involve design and synthesis of chemical tools, testing in KDM-relevant assays, and then testing in cell-based assays studying cell function and inflammation. The student will learn a diverse range of skills through rotations in each of the supervisors’ laboratories and will benefit from a highly interdisciplinary training environment.

Informal enquiries may be made to

HOW TO APPLY

Applications should be made by emailing with a CV and a covering letter, including whatever additional information you feel is pertinent to your application; you may wish to indicate, for example, why you are particularly interested in the selected project/s and at the selected University. Applications not meeting these criteria will be rejected. We will also require electronic copies of your degree certificates and transcripts.

In addition to the CV and covering letter, please email a completed copy of the Application Details Form (Word document) to , noting the additional details that are required for your application which are listed in this form. A blank copy of this form can be found at: https://www.nld-dtp.org.uk/how-apply.


Funding Notes

Studentships are funded by the Biotechnology and Biological Sciences Research Council (BBSRC) for 4 years. Funding will cover tuition fees at the UK rate only, a Research Training and Support Grant (RTSG) and stipend. We aim to support the most outstanding applicants from outside the UK and are able to offer a limited number of bursaries that will enable full studentships to be awarded to international applicants. These full studentships will only be awarded to exceptional quality candidates, due to the competitive nature of this scheme.
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