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Intra-articular of an anti-inflammatory molecule entrapped in a solid lipid nanoparticle


   The Conway Institute of Biomolecular and Biomedical Research

   Friday, July 15, 2022  Funded PhD Project (Students Worldwide)

About the Project

Patients with arthritic knees are limited in their therapy options to orally-administered anti-inflammatory agents, which are toxic over the long term. When the disease becomes more severe, the two main options are steroid and hyaluronic acid injections into the knee. The outcomes are sub-optimal, largely because joint retention is low, hence the need for more regular painful injections. The project will examine how to make a long-acting injectable lipid nanoparticle formulation of an anti-inflammatory prodrug steroid molecule. Questions the candidate will pursue are to devise a bespoke formulation of the molecule for entrapment in a solid lipid nanoparticle, how to optimise the loading and release of the molecule from nanoparticles in simulated joint conditions, how the particle-released drug retains its anti-inflammatory effects on cultured human synoviocytes, and safety and efficacy assessment in a preclinical animal model of arthritis. The Brayden lab has experience of making nanoparticles to treat arthritis, has access to an Ignite™ solid lipid nanoparticle synthesis system from Precision Nanosystems, and is also part of the SFI CÚRAM Centre for Medical Devices with access to national expertise. The candidate will be working under the supervision of Prof. David Brayden in the UCD School of Veterinary Medicine and UCD Conway Institute: https://people.ucd.ie/david.brayden


Funding Notes

SFI CÚRAM Centre for Medical Devices and the EU.

References

Relevant papers relating to how the Brayden lab has made other nanoparticle constructs for arthritis are at: https://pubmed.ncbi.nlm.nih.gov/23391443/ and https://pubmed.ncbi.nlm.nih.gov/29947020/

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