This project aims to characterise some of the fundamental interactions between motor neurons and glial cells (microglia, astrocytes, and oligodendrocytes) in the CNS.
The key challenges for determining the diverse roles of glia has been the ability to evaluate the individual (molecular) profile of activated glial cells, and to identify the spectrum of functional responses that these cells can display as a result of their activation. We have developed an experimental workflow that will allow direct in vivo live-tracking of a single glial cells throughout its response to neuronal injury, and correlate this directly with the same cell’s transcriptome.
We are looking for an enthusiastic and motivated team member, whose work will involve the generation of transgenic zebrafish, latest CRISPR tools, implementing novel molecular tools, and performing high-end confocal microscopy. Our lab has developed advance molecular techniques to characterise cell-to-cell interactions in the zebrafish spinal cord on a single cell level and in real-time (https://doi.org/10.1007/s00401-018-1875-2; https://doi.org/10.3389/fncel.2015.00321).
We are looking for a motivated individual with a keen interest in neurodegenerative diseases (we have a focus on MND/ALS), who is eager to learn and work with zebrafish, open to develop novel techniques, and work as part of a larger team.
About us: We are an inclusive team of neuroscientists with a passion for understanding the cellular and molecular drivers in the CNS. We are multicultural, dynamic, and value a healthy work-life balance.
If this sounds like it could be for you, please get in touch.
Prospective candidates should contact Dr Marco Morsch for more information.