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Investigate the mechanism by which vaccinia virus exploits microtubules to transport new virions to the cell periphery

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  • Full or part time
    Prof G L Smith
  • Application Deadline
    No more applications being accepted
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

Vaccinia virus is the live vaccine that was used to eradicate smallpox. After smallpox eradication, VACV has been exploited to build vaccines against other diseases and continues to be studied to better understand virus interactions with the host cell and the immune system. This project will study how vaccinia virus exploits the kinesin-1 motor to transport newly synthesised virus particles on microtubules to the cell periphery. Specifically, the project with study the functions of the virus proteins A36, F12 and E2 in this process and the cellular proteins to which they bind, such as kinesin light chains 1 and 2.

Funding Notes

The position is available from October 2019 or as soon thereafter as the suitable candidate can start.

Applicants should have a 1st or upper second class degree in biological or medical sciences and preferably some experience of working in a research environment.

References

Doceul, V., Hollinshead, M., van der Linden, L. & Smith, G.L. (2010). Repulsion of superinfecting virions: a mechanism for rapid virus spread. Science, 327, 873-7.

Carpentier, D.C.J., Gao, W.N.D., Ewles, H., Morgan, G.W. & Smith, G.L. (2015). Vaccinia virus protein complex F12/E2 interacts with kinesin light chain isoform 2 to engage the kinesin-1 motor complex. PLoS Pathogens. 11, e1004723.

Gao, W.N.D., Carpentier, D.C.J., Ewles, H.A., Lee, S.-A. & Smith, G.L. (2017). Vaccinia virus proteins A36 and F12/E2 show strong preferences for different kinesin light chain isoforms. Traffic 18, 505-18.

Carpentier, D.C.J., Van Loggerenberg, A., Dieckmann, N.M.G. & Smith, G.L. (2017). Vaccinia virus egress mediated by protein A36 is reliant on the F12 protein. J. Gen. Virol. 98, 1500-14.



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