The project will investigate novel anti-inflammatory, anti-cancer and anti-fibrotic approaches to treatment using naturally occurring omega-3-polyunsaturated fatty acids (Ω-3-PUFA’s) and their derivatives in ex vivo and in vitro model systems. The health benefits of these substances, derived from fish oils and widely consumed as nutritional supplements, have been known for some time. However, although their uses are becoming more widespread there is still little known about their mechanisms of action. It is expected that you will actively contribute with intellectual input into all phases of the project (e.g., design, analysis, etc). The results of this PhD have the potential to influence future treatment strategies in globally-significant diseases. It is anticipated that this project will also result in the publication of high impact peer-reviewed scientific papers.
Further details: The project offers the opportunities to develop clinical collaborations with University Hospital South Manchester NHS Foundation Trust and Salford Royal NHS Foundation Trust. Funding will be available for presentation of work at appropriate international scientific meetings