Blood Cells are used daily in medical and cancer treatments such as transfusions, bone marrow / haematopoietic stem cell (HSCs) transplantations, and immunotherapies. The main aim of this project is to understand how these different blood cells are generated during development deploying state of the art approach such as in vivo/in vitro mouse models, flow cytometry, single-cell RNA and ATAC-seq, spatial transcriptomic and bioinformatic integration of large scale high dimensional single-cell multi-modal omics. The long-term goal is to identify the molecular programs driving the generation of different types of blood cells. Such knowledge would allow to generate from pluripotent stem cells unlimited source of therapeutically relevant cell products such as modified natural killer cells, chimeric antigen receptor T-cells, modified red blood cells, platelets, or haematopoietic stem cells.
1.Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree in biology or computer science. Candidates with experience in haematopoiesis or with an interest in single cell omics technologies are encouraged to apply.
2. For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (https://www.bmh.manchester.ac.uk/study/research/apply/). Informal enquiries may be made directly to the primary supervisor. On the online application form select the PhD title.
3. For international students, we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences. For more information please visit www.internationalphd.manchester.ac.uk