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Investigating how cross-talk between melanoma and the tumour microenvironment promote metastasis.

  • Full or part time
  • Application Deadline
    Friday, May 17, 2019
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

We are seeking an outstanding graduate for a fully funded PhD studentship investigating melanoma metastasis. The tumour microenvironment (TME) is a critical determinant of cancer progression and clinical outcome. The major component of the TME are cancer-associated fibroblasts (CAFs), which communicate with tumour cells influencing tumour growth, invasion, metastasis and chemoresistance. CAFs can interface with tumours by secreting small membrane-bound vesicles called exosomes that contain mircoRNAs (miRNAs). We have evidence that melanoma CAF exosomes contain miRNAs known to drive cancer and here we will determine how these miRNAs are promoting melanoma progression. This represents an understudied area of melanoma research and will identify novel therapeutic targets and potential prognostic biomarkers present in the TME. The successful applicant will receive training and gain expertise in a wide-range of cutting-edge molecular biology techniques, including primary human cell culture, non-coding RNA analysis, next-generation sequencing, qRT-PCR, protein biochemistry and and cancer phenotypic assays.

Applicants

The successful applicant will have a first or very good upper second-class BSc (Hons) or MSc in a relevant subject. The programme will commence September 2019.

How to Apply

To apply, send a CV and personal statement to Dr Jim Boyne () before 5pm on Friday 17th May. Please clearly state that this is the project you intend to apply for.

Funding Notes

This position is funded by the British Skin Foundation and is open to UK/Eu citizens only. The studentship covers the full cost of tuition fees and an annual tax-free bursary of £15,009 for three years (UKRI rates).

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