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Click here to search FindAPhD.com for PhD studentship opportunitiesAbout the Project
Frontotemporal dementia (FTD) is the 2nd most common form of dementia affecting younger people, with a typical age of onset in the mid-late 50s. Unlike Alzheimer’s disease, memory is relatively preserved in FTD patients. However, FTD is a debilitating disease causing severe personality changes, changes in social behaviour, loss of inhibition, irrational behaviours and changes in emotional processing. Around 15% of FTD patients also develop motor neuron disease (MND, also known as ALS). MND is characterised by selective degeneration of motor neurons, leading to progressive muscle wasting, weakness and paralysis. MND is almost invariably fatal within 2-5 years of symptomatic onset. There are no effective treatments currently available for either FTD or MND. Our research aims to better understand the molecular and cellular mechanisms underlying disease processes in FTD/MND, and identify potential therapeutic targets for both diseases. We are particularly interested in how immune dysfunction contributes to FTD/MND disease pathogenesis.
Neuroinflammation is a common feature of all neurodegenerative diseases, including FTD/MND. Increased microglial activation is observed in affected brain regions, and several pro-inflammatory cytokines are known to be elevated in patient blood and cerebrospinal fluid. We know from research into other neurodegenerative diseases that excessive inflammation can damage the brain and may contribute to neuronal dysfunction and cognitive impairments. However, this has been relatively understudied in FTD/MND. This project will investigate the causes of inflammation in FTD/MND, as well as the downstream consequences of inflammation on neuronal function and neurodegeneration.
Training/techniques to be provided
Our group uses a combination of cell culture and in vivo mouse models to study FTD/ALS. The successful candidate will learn a wide range of research techniques such as cell culture, behavioural assays to test motor and cognitive function in mice, immunohistochemistry, microscopy, ELISA, Western blotting and PCR.
Entry Requirements
Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in a related area / subject. Candidates with experience in cell culture or in vivo techniques, or with an interest in neurodegenerative disease are encouraged to apply.
How to Apply
For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (https://www.bmh.manchester.ac.uk/study/research/apply/). Informal enquiries may be made directly to the primary supervisor. On the online application form select the PhD Neuroscience and Experimental Psychology.
For international students, we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences. For more information please visit https://www.bmh.manchester.ac.uk/study/research/international/
Equality, Diversity & Inclusion
Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. The full Equality, diversity and inclusion statement can be found on the website
https://www.bmh.manchester.ac.uk/study/research/apply/equality-diversity-inclusion/
Funding Notes
Details of our different fee bands can be found on our website https://www.bmh.manchester.ac.uk/study/research/fees/
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