About the Project
Alcoholic liver disease is one of the commonest causes of liver disease. The damage that arises can be both acute and/or chronic and with time can lead to liver cirrhosis, with alcohol abuse the leading cause of mortality due to liver cirrhosis. Furthermore, liver disease is projected to overtake heart disease as the leading cause of premature deaths by 2020. Despite this, the precise mechanisms involved in disease progression from fatty liver to hepatitis to fibrosis are still poorly understood, but are likely to involve mitochondrial injury, free radical damage, iron dysregulation, innate immune response and endotoxin mediated inflammation. The aims of this project are to investigate how these factors induce liver injury and correlate with disease severity, utilising a combination of in vitro cell line model approach, using a specific alcohol metabolising cell line, as well as clinical samples from alcoholic patients. A variety of biochemical, molecular and imaging techniques will be employed to study cellular pathways and metabolic processes. The project will also study both natural and synthetic compounds in their capacity to ameliorate liver damage. Aspects of alcohol addiction from a behavioural side will also be studied.
Informal enquiries to Dr Vinood Patel [Email Address Removed]
Dr Patel’s Publications can be accessed via
https://www.researchgate.net/profile/Vinood_Patel/publications
https://westminsterresearch.westminster.ac.uk/researcher/889q0
References
Mehta KJ, Coombes JD, Briones-Orta M, Manka PP, Williams R, Patel VB, Syn WK. Iron Enhances Hepatic Fibrogenesis and Activates Transforming Growth Factor-β Signaling in Murine Hepatic Stellate Cells. Am J Med Sci. 2018 355(2):183-190.
Riva, A., Patel, V., Kurioka, A., Jeffery, H.C., Wright, G., Tarff, S., Shawcross, D., Ryan, J.M., Evans, A., Azarian, S., Bajaj, J.S., Fagan, A., Patel, V., Mehta, K., Lopez, C., Simonova, M., Katzarov, K., Hadzhiolova, T., Pavlova, S., Wendon, J.A., Oo, Y.T., Klenerman, P., Williams, R. and Chokshi, S. Mucosa-associated invariant T cells link intestinal immunity with antibacterial immune defects in alcoholic liver disease. Gut 2018 67, 918-930
Mehta K, Busbridge M, Renshaw D, Evans RW, Farnaud S, Patel VB. Characterization of hepcidin response to holotransferrin in novel recombinant TfR1 HepG2 cells Blood Cells Mol Dis. 2016 61:37-45
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