Investigating molecular drivers of cell invasion


   Division of Cancer Studies

  Prof Claire Wells  Applications accepted all year round  Awaiting Funding Decision/Possible External Funding

About the Project

The Wells laboratory focusses on exploring the molecular mechanisms that underlie cell invasion. We have interests in cancer cell invasion and hemopoietic cell invasion. These interests converge on the p-21 activated kinase signalling pathway. As cancer cells and immune cells form part of the overall tumour microenvironment the study of both cell types is equally important to developing novel cancer therapies. We use a range of cell biology, microscopy, biochemistry and genomic approaches to investigate cell invasion. Prof Wells has a 100% PhD success rate and has supervised 12 students to award. Prof Wells has experience of supervising students from all funding backgrounds including self -funded. The Wells lab is an inclusive environment where all members are treated with respect. Our projects aim to understand how p-21 activated kinases regulate cell adhesion and thus cell invasion. Find out more about the lab here https://www.kcl.ac.uk/research/invasion-and-metastasis-research-group.

There are currently two funded opportunities

Project 1: Project Reference: MM4L23

Deep learning approaches for deciphering cellular interactions from image data

https://www.kcl.ac.uk/dentistry/research/multiscale-models-for-life-mm4l-centre-for-doctoral-training

Project 2: Digital twins for histopathology toward personalised cancer treatment

https://www.kcl.ac.uk/research/dt4health-cdt-projects.

If you want to apply to either project please do so via the website I cannot accept applications sent directly to me.

For enquiries about self-funding projects please contact Prof Wells directly.

Biological Sciences (4)

References

Manuelli V, Cahill F, Wylie H, Gillett C, Correa I, Heck S, Rimmer A, Haire A, Van Hemelrijck M, Rudman S, Wells CM. (2022) Invadopodia play a role in prostate cancer progression. BMC Cancer. 22:386. doi: 10.1186/s12885-022-09424-4
Elizabeth Foxall, Adela Adela Staszowska, Liisa Hirvonen, Mirella Georgouli, Mariacristina Ciccioli, Alexander Rimmer, Yolanda Calle, Victoria Sanz Moreno, Susan Cox, Gareth E Jones and Claire M. Wells (2019) PAK4 kinase activity plays a crucial role in the podosome ring of myeloid cells. Cell Rep.; 29(11):3385-3393.e6. doi: 10.1016/j.celrep.2019.11.016.
Anna Dart, Gary Box , William Court , Madeline Gale, John Brown, Sarah Pinder, Sue Eccles and Claire M Wells (2015) PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. J Cell Biol. 211:863-79. doi: 10.1083/jcb.201501072.