Mutations in DNA are known to directly contribute to the development of cancers. In recent years, research, including those from our own group (Nature 2016, Cell Reports 2016, NAR 2017, PLoS Genetics 2018) have begun to shed light on mutational processes – linking mutagen exposure, DNA repair and epigenetic factors in governing how certain mutations form across cancer genomes. We currently have several projects that integrate computational, next-generation sequencing and mass spectrometry-based techniques to further our understanding of mutational processes. The outcomes of this project will not only further our fundamental knowledge of cancer mutational processes but will also have a direct translational impact, potentially providing oncologist with new tools to select the most effective treatments for their patients.
We are seeking candidates with a strong interest in the fields of DNA damage/repair and cancer genomics. We are open to candidates with either computational or laboratory skills. Experience in mass spectrometry will be an advantage. All students in my laboratory can expect to develop skills in computational biology and bioinformatics.