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Investigating neuronal dynamics of memory circuits


Nuffield Department of Clinical Neurosciences

About the Project

Applications are invited from both Home students and International students to join a multidisciplinary team of scientists studying neural dynamics of memory circuits in the rodent brain. Up to two studentships are available from the start of academic year 2021/22, for 3 years each, and both will be primarily supervised by Professor David Dupret at the Medical Research Council Brain Network Dynamics Unit at the University of Oxford (MRC BNDU). The overall aim of these studentship projects is to investigate how neuronal activities distributed across brain regions support complex, multimodal memories where acquired information spans the sensory, motor and cognitive domains. Notably, we will investigate the concerted action of groups of neurons scattered across brain regions as well as frequency-specific network oscillations in memory tasks. These projects will also involve identifying electrophysiological signals in real-time to implement closed-loop neuromodulation that interacts with brain activities. For further details about these projects, contact Professor David Dupret () and see the MRC BNDU’s Studentships page: https://www.mrcbndu.ox.ac.uk/phd

Interested candidates should possess, or expect to receive, a 1st class or upper 2nd class degree (or equivalent) in a related scientific discipline, e.g. biological or physical sciences, medicine, computer science, engineering, mathematics. Previous experience in neuroscience research is essential. This includes clear contribution to either in vivo electrophysiological recordings, behavioural assays of learning and memory in rodents, and/or data analyses and programming (e.g., Python, R, and Jupyter). Note that appointed students will be offered the possibility to either actively engage with all of these techniques, or concentrate on the analyses of existing electrophysiological datasets that comprise spike trains and local field potentials.

The MRC BNDU is uniquely multidisciplinary, integrating exceptional research programmes that span clinical, experimental and computational neuroscience and bioengineering. The collective aim of the MRC BNDU is to understand the moment-to-moment interactions between nerve cells that are critical for brain functions, and to exploit these to develop novel therapies for disorders such as Parkinson’s disease.

These Ph.D. (D.Phil.) studentships are funded by the Medical Research Council (MRC), a part of UKRI. All successful applicants are entitled to receive a tax-free stipend and, as a minimum, tuition fees paid at the Home level, regardless of whether they are Home or International students. For further details about MRC/UKRI studentships and updated guidance regarding Home and International eligibility, please see: https://www.ukri.org/our-work/developing-people-and-skills/find-studentships-and-doctoral-training/get-a-studentship-to-fund-your-doctorate/

To be considered for this studentship, please submit an application for admission to the D.Phil. in the Nuffield Department of Clinical Neurosciences (course code RD_CU1), following the guidance at https://www.ox.ac.uk/admissions/graduate/courses/dphil-clinical-neurosciences?wssl=1. On the application form, in the section headed ‘Departmental Studentship Applications’, please indicate that you are applying for a studentship and enter the reference code for a MRC BNDU studentship "21CLINNEURO01WEB".

The closing date for applications is 12.00 midday UK time on Friday 8th January 2021.

Interviews for short-listed applicants will be held between 25th and 28th January 2021.


Weblinks:
https://www.mrcbndu.ox.ac.uk/groups/dupret-group

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