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Investigating Noise in Ageing Cellular Power Stations

  • Full or part time
    Dr Nick Jones
  • Application Deadline
    Applications accepted all year round
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

About This PhD Project

Project Description

PhD Project: Imperial College Mathematics

Student Background: Theoretical Physics, Mathematics/Statistics, Electrical Engineering (Biological knowledge not required)

or Quantitative Biology with an interest in experiment.

We have been investigating (genetic) variation in cellular power stations (mitochondria) using a mix of ideas from stochastic population processes, statistical physics, statistical inference and control theory. You can read more about our recent work in our blog: http://systems-signals.blogspot.co.uk/ We believe this is a particularly exciting area to study for two reasons. Not only does 1) mitochondrial (dys)function have deep connections to therapies for conditions like Parkinsons, Diabetes, ageing and Cancer (and we are working on these) it is 2) a topic that, though poorly understood, might be susceptible to the very basic (though mathematically nuanced) models that one constructs in theoretical and mathematical physics. This is an area where students can explore out a new scientific direction since the medical promise and scientific opportunities easily exceed the number of theorists. The student will investigate the construction of such basic models and make connections with existing data and the work of our national and international collaborators (Cambridge, UCL, Madrid, Vienna). Though the project has experimental collaborators the project does not require experiments by the student or any biological background; however theorists that want to try their hand at experiment are most welcome.

If you are an experimentalist we are also interested in possible collaborations e.g. with Prof Patrick Chinnery in Cambridge -- please send your CV.

We are looking for passion and scientific intuition. We specifically welcome students from underrepresented groups.

You can learn about the research of the systems and signals group on our site:
https://www.imperial.ac.uk/people/nick.jones/research.html
and from our blog:
http://systems-signals.blogspot.co.uk/
Our group is a member of Imperial’s EPSRC Centre for the Mathematics of Precision Healthcare:
http://www.imperial.ac.uk/mathematics-precision-healthcare

Further enquiries - contact with a CV detailing academic performance (i.e. including as detailed as possible information about grades/marks or equivalent):
Nick Jones (Imperial Mathematics) https://www.imperial.ac.uk/people/nick.jones

We also have a project linking health behaviour to statistical inference here:
https://www.findaphd.com/search/ProjectDetails.aspx?PJID=91515

References

https://www.imperial.ac.uk/people/nick.jones/page/non-auto-papers.html

http://systems-signals.blogspot.co.uk/

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