This project is available to UK/EU candidates. Funding covers fees and stipend for 3.5 years. Candidates will be required to split their time between Manchester and Melbourne.
Applications should be submitted online and candidates should make direct contact with the Manchester supervisor to discuss their application directly. Applicants must have obtained, or be about to obtain, at least an upper second class honours degree (or equivalent) in a relevant subject.
As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.
Dr Michael Harte
Almari, B, Harte, M, Brough, D & Tirella, A (2019), 'Fabrication of Amyloid-β-Secreting Alginate Microbeads for Use in Modelling Alzheimer's Disease', Journal of Visualized Experiments.
Sellers, KJ, Elliott, C, Jackson, J, Ghosh, A, Ribe, E, Rojo, AI, Jarosz-Griffiths, HH, Watson, IA, Xia, W, Semenov, M, Morin, P, Hooper, NM, Porter, R, Preston, J, Al-Shawi, R, Baillie, G, Lovestone, S, Cuadrado, A, Harte, M, Simons, P, Srivastava, DP & Killick, R (2018), 'Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil', Alzheimer's & dementia : the journal of the Alzheimer's Association.
Watremez, W, Jackson, J, Almari, B, McLean, SL, Grayson, B, Neill, JC, Fischer, N, Allouche, A, Koziel, V, Pillot, T & Harte, MK (2018), 'Stabilized Low-n Amyloid-β Oligomers Induce Robust Novel Object Recognition Deficits Associated with Inflammatory, Synaptic, and GABAergic Dysfunction in the Rat', Journal of Alzheimer's disease : JAD, vol. 62, no. 1, pp. 213-226.
Daniels, MJD, Rivers-Auty, J, Schilling, T, Spencer, NG, Watremez, W, Fasolino, V, Booth, SJ, White, CS, Baldwin, AG, Freeman, S, Wong, R, Latta, C, Yu, S, Jackson, J, Fischer, N, Koziel, V, Pillot, T, Bagnall, J, Allan, SM, Paszek, P, Galea, J, Harte, MK, Eder, C, Lawrence, CB & Brough, D (2016), 'Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models', Nature Communications, vol. 7, 12504, pp. 12504.
Dr Peter Crack
Moore Z, Taylor JM, Crack PJ (2019) The involvement of microglia in Alzheimer's disease: a new dog in the fight. Br J Pharmacol. Sep;176(18):3533-3543.
Taylor JM, Moore Z, Minter MR, Crack PJ (2018) Type-I interferon pathway in neuroinflammation and neurodegeneration: focus on Alzheimer's disease. J Neural Transm (Vienna). May;125(5):797-807.
Minter MR, Moore Z, Zhang M, Brody KM, Jones NC, Shultz SR, Taylor JM, Crack PJ (2016) Deletion of the type-1 interferon receptor in APPSWE/PS1ΔE9 mice preserves cognitive function and alters glial phenotype. Acta Neuropathol Commun. Jul 11;4(1):72.
Minter MR, Main BS, Brody KM, Zhang M, Taylor JM, Crack PJ (2015) Soluble amyloid triggers a myeloid differentiation factor 88 and interferon regulatory factor 7 dependent neuronal type-1 interferon response in vitro. J Neuroinflammation Apr 12;12:71