About the Project
In this project, the student will use the tools of molecular and cellular biology to determine the mechanisms by which these novel homeobox oncogenes function to drive proliferation, repress cell death, regulate differentiation and activate oncogenic signalling pathways. The broad aims of the projects will include;
1. Determining how these fusions regulate differentiation programs using in vitro and in vivo model systems.
2. Identifying where in the genome the fusions bind, the molecular complexes in which they function, and the changes in gene expression they induce.
3.Use high-throughput drug screens to identify potential targeted therapies.
This project will engage the student in cancer biology and the generation of new models to study these fusion genes. Techniques such as CRISPR/Cas9 to modify genes and generate generate endogenous fusions, RNA sequencing, ChIP sequencing, protein analysis including phosphoproteomics will be employed in this project and the student will develop valuable skills in these methodologies.
The overall aim of this project is to determine the mechanisms by which homeobox fusion oncogenes drive cancer and use this molecular insight to identify ways in which these novel fusions can be therapeutically targeted.
All students at the Institute must fulfil the requirements for enrolment at UNSW to undertake their PhD with us as well as obtain a scholarship that will cover both your living expenses and tuition fees. Scholarship and entry requirements will be provided on request.
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