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Investigating the contribution of liver sinusoidal endothelial cell gene regulatory networks in hepatic homeostasis and disease

Project Description

The BHF 4-year MRes/PhD studentships at ICTEM typically comprises a 1-year MRes in Biomedical Research, followed by a 3-year PhD. During the MRes year, students undertake two projects which will prepare them for the PhD.

The project will investigate how genetic and/or epigenomic mechanisms causing dysregulation of gene regulatory mechanisms in liver sinusoidal endothelial cells (LSEC) contribute to cardiometabolic diseases, such as non-alcoholic fatty liver disease and cardiovascular disease. To this end, the candidate will generate appropriate in vitro cellular models to study LSEC gene regulatory networks, deploy state-of-the-art epigenomic assays, such as ATAC-seq and Cut&Run, and apply functional validation techniques, including CRISPR/Cas9 genome editing, to identify and characterise disease mechanisms. This project will require application of both experimental and computational approaches by the student.

The successful candidate will be based in the Cebola, Randi and Birdsey labs at the Hammersmith Campus the period of their study. They will join a cohort of PhD. students affiliated with the BHF Centres at Imperial, with particular interests in cardiovascular medicine and novel technologies. They will also link to the wider Imperial College through multiple training opportunities provided throughout the course of the studentship.

To apply, you will need to complete the following two steps:

1) Please email Veena Dhulipala () with the following documents.

- Your CV
- The names and addresses of at least two academic referees
- A personal statement of no more than 1,000 words explaining your interest in the project

2) Please complete the Imperial College London’s online application site (

Please note that you will have to complete both steps for your application to be considered. Please assume that your application has not been successful if you have not heard from us within a month of the closing date.

Closing date for all applications: 23.59 on Sunday 19th January 2020

Interviews will be held in early February 2020

Funding Notes

Applicants must hold, or expect to obtain, a first or upper second-class honours degree or equivalent in an appropriate subject from a recognised academic institution. Candidates must fulfill College admissions criteria and meet BHF residency requirements.

This is a highly interdisciplinary project and previous theoretical and practical experience in at least one of the areas of the following is essential: bioinformatics (including bash, python and/or R coding), cell culture, molecular cloning, qRT-PCR, CRISPR/Cas9 genome editing, lentiviral production, and chromatin immunoprecipitation.

Related Subjects

How good is research at Imperial College London in Clinical Medicine?

FTE Category A staff submitted: 334.18

Research output data provided by the Research Excellence Framework (REF)

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