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Investigating the effects of inflamm-aging on the safety and efficacy of monoclonal antibody based therapies


   Biosciences Institute

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  Prof Kevin Marchbank, Dr Andy Watts  No more applications being accepted  Competition Funded PhD Project (Students Worldwide)

About the Project

Our understanding of the immune response in the elderly is still in its infancy. Now, more than ever we need to understand the basic principles of immune response as the environment alters our immune system and the particles it sees. We have developed several sophisticated models of unhealthy aging in mice and have teamed up with a company interested in understanding how to make drugs work better and more safely in patients. This innovative research project will therefore be addressing two key priorities –helping to understand how our immune system changes with age and bad diet and how these changes may contribute to a loss of safety and function of antibody-based therapies in complex diseases of the ageing. We will be using common monoclonal antibody-based therapies and assessing how the immune system reacts to these over time. We will be using sophisticated biochemical and immunological analysis to tease apart the cellular and molecular interactions that drive unwanted responses to these medicines. The work will help lead to better understanding of basic immunology of ageing as well as help to provide strategies to avoid unwanted drug interactions. You would carry out this research in state of the art labs and be part of the thriving immunology department. You would visit and carry out research with our industry partner. You would be also be part of a National Therapeutics Centre and as such interact with a highly skilled and motivated team of clinicians, clinical scientist, industrial scientists and academics. The industrial placement will be structured in such a way to give the student a chance to drive a mini–project from conception to conclusion. There will be multiple visits to the company and associated labs across the project and therefore you will learn the full journey of basic research through to applied practise. The research will be immunological, pharmaceutical and biochemical by discipline while having a strong grounding in business acumen. 

The studentship should be commenced before the end of 2022.

HOW TO APPLY

Applications should be made by emailing [Email Address Removed] with:

·      a CV (including contact details of at least two academic (or other relevant) referees);

·       a covering letter – clearly stating your first choice project, and optionally 2nd ranked project, as well as including whatever additional information you feel is pertinent to your application; you may wish to indicate, for example, why you are particularly interested in the selected project(s) and at the selected University;

·      copies of your relevant undergraduate degree transcripts and certificates;

·      a copy of your passport (photo page).

A GUIDE TO THE FORMAT REQUIRED FOR THE APPLICATION DOCUMENTS IS AVAILABLE AT https://www.nld-dtp.org.uk/how-apply. Applications not meeting these criteria may be rejected.

In addition to the above items, please email a completed copy of the Additional Details Form (as a Word document) to [Email Address Removed]. A blank copy of this form can be found at: https://www.nld-dtp.org.uk/how-apply.

Informal enquiries may be made to [Email Address Removed]. The closing date for applications is Friday 8th July 2022 at 12noon (UK time).


Funding Notes

CASE studentships are funded by the Biotechnology and Biological Sciences Research Council (BBSRC) for 4 years. Funding will cover tuition fees at the UK rate only, a Research Training and Support Grant (RTSG) and stipend. We aim to support the most outstanding applicants from outside the UK and are able to offer a limited number of bursaries that will enable full studentships to be awarded to international applicants. These full studentships will only be awarded to exceptional quality candidates, due to the competitive nature of this scheme. Note that home (UK) candidates may also apply to this studentship.

References

Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice. J Clin Invest. 2019 Mar 1;129(3):1061-1075. doi: 10.1172/JCI99296. Epub 2019 Feb 4. PubMed PMID: 30714990; PubMed Central PMCID:PMC6391106.
Utilization of Staphylococcal Immune Evasion Protein Sbi as a Novel Vaccine Adjuvant. Front Immunol. 2019 Jan 11;9:3139. doi: 10.3389/fimmu.2018.03139. eCollection 2018. PubMed PMID: 30687332; PubMed Central PMCID: PMC6336717.
A novel C3d-containing oligomeric vaccine provides insight into the viability of testing human C3d-based vaccines in mice. Immunobiology. 2018 Jan;223(1):125-134. doi: 10.1016/j.imbio.2017.10.002. Epub 2017 Oct 4. PubMed PMID: 29017821; PubMed Central PMCID: PMC5849677.
Defective B cell ontogeny and humoral immune response in mice prematurely expressing human complement receptor 2 (CR2, CD21) is similar to that seen in aging wild type mice. Mol Immunol. 2009 Jun;46(10):2002-13. doi: 10.1016/j.molimm.2009.03.007. Epub 2009 Apr 8. PMID: 19359041.
Evaluation of the physiochemical and functional stability of diluted REMSIMA® upon extended storage—A study compliant with NHS (UK) guidance Int J Pharmaceut. 2015, 496, 2, p. 421-431. doi:10.1016/j.ijpharm.2015.10.016
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