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Investigating the impact of cellular state on cryopreservation


   Warwick Medical School

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  Prof Matthew Gibson  No more applications being accepted  Funded PhD Project (Students Worldwide)

About the Project

PhD in Interdisciplinary Biomedical Research

Fully funded studentship available for entry in September 2022

This industrial Collaborative Award in Science and Engineering (iCASE) studentship is offered by Warwick’s MRC Funded Doctoral Training Partnership (DTP). The training program involves an exciting one-year MSc in Interdisciplinary Biomedical Research and then a three-year PhD project, co-supervised by experts from both academia and industry. Students join a dynamic DTP community, which includes advanced workshops, transferable skills training, careers support and cohort learning events and conferences with ~50 other students.

We are constantly working to create a supportive and inclusive environment to help students achieve their best potential, through promoting equality and challenging discrimination. We want our students to feel heard and valued for their hard work. We welcome and encourage applications from minoritised groups that are under-represented in academia.

Project summary

Cell cryopreservation is essential for drug screening, delivery of cell-based therapies and basic biomedical research. There has been a major focus on the cryoprotectants and the optimisation of external factors such as freezing rate. In this industry/academic research project we will explore how the biochemical state of the cell when frozen impacts its cryopreservation outcomes. We will use chemical and physical stimuli to induce certain cell states, including parts of the cell cycle, and quantify the impact of this on the quality of the recovered cells. The project will give a student the chance to undertake fundamental cell biology research whilst working with a major life science company, including undertaking placements at the industry partner’s research site. The outputs from this work will further improve our understanding of how cells prepare for cold stress, inspired by extremophiles in nature, as well as new tools/methods to improve cell-based therapies.

Industry Partner: Cytivia

PROGRAMME CONTENT

Year One l MSc

Students undertake a series of taught modules, including Frontier Techniques in Biomedical Research, Physical Biology of the Cell, Microscopy and Imaging, Mathematical Modelling, Mass Spectrometry, and two laboratory-based research projects. 

Years Two, Three and Four l PhD project

Student support

Students receive outstanding mentoring, careers and pastoral support throughout the programme.

ENTRY REQUIREMENTS, FUNDING AND HOW TO APPLY

Entry requirements

Candidates must have:

  • An excellent undergraduate degree (2:i or above) in the biological, physical or computational sciences; and ideally a background in cell culture/biology or bio-materials engineering.
  • Advanced skills in mathematics (A-Level or international equivalent).  

How to apply

If you are interested in joining our DTP community, please apply here by 15 February 2022. Interviews will take place in the week commencing 4 April 2022.

For further information please see warwick.ac.uk/mrcdtp


Funding Notes

Studentships cover full fees, consumables, conference attendance and an annual stipend (£18,340 in 2022/23*). Students can also apply for additional funding from the DTP for advanced training workshops, international or industry placements, internships and career transition support.
* Estimated stipend amount; exact figure to be confirmed
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